FITC标记的视神经视网膜相关蛋白VAX1抗体上海沪震实业有限公司

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产品名称: FITC标记的视神经视网膜相关蛋白VAX1抗体
英文名称: Anti-VAX1/FITC
抗体货号: HZ-11496R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/13 14:20:00
详细资料:  实验方法技术资料
浏览人数:14
诚信指数:1034点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-VAX1/FITC Conjugated antibody

FITC标记的视神经视网膜相关蛋白VAX1抗体

 

产品编号 bs-11496R-FITC
英文名称 Anti-VAX1/FITC
中文名称 FITC标记的视神经视网膜相关蛋白VAX1抗体
别    名 VAX1; VAX1_HUMAN; ventral anterior homeobox 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VAX1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. VAX1 (ventral anterior homeobox 1) is a 334 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed as multiple alternatively spliced isoforms, VAX1 is required for major tract formation and axon guidance in the developing brain and may play a role in the differentiation of various structures, including the optic stalk, the neuroretina and the pigmented epithelium. The gene encoding VAX1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

Function:
Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk.

Subcellular Location:
Nucleus.

DISEASE:
Defects in VAX1 are the cause of microphthalmia, syndromic, type 11 (MCOPS11) [MIM:614402]. A rare clinical entity including as main characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of corpus callosum, hippocampal malformations, and absence of the pineal gland. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.

Similarity:
Belongs to the EMX homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:
Entrez Gene: 11023 Human
Entrez Gene: 22326 Mouse
Entrez Gene: 64571 Rat
Omim: 604294 Human
SwissProt: Q5SQQ9 Human
SwissProt: Q2NKI2 Mouse
SwissProt: Q9JM00 Rat
Unigene: 441536 Human
Unigene: 23801 Mouse
Unigene: 48764 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

同源盒DNA结合域是一个60个氨基酸的基序,在许多物种中是保守的,其功能是通过螺旋-螺旋-螺旋结构结合DNA,从而在转录调控和基因表达调控中发挥作用。VAX1(腹前同源盒1)是一种334个氨基酸的蛋白质,定位于细胞核并含有一个同源盒DNA结合结构域。表达为多个交替剪接的亚型,VAX1是需要的主要道形成和轴突引导在发育中的大脑,并可能发挥作用的各种结构的分化,包括视神经茎,神经视网膜和色素上皮。编码VAX1的基因映射到人类10号染色体,该基因含有1200个以上的基因,并包含人类基因组的近4.5%。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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