FITC标记的多重表皮生长因子样蛋白4抗体上海沪震实业有限公司

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产品名称: FITC标记的多重表皮生长因子样蛋白4抗体
英文名称: Anti-Slit1/FITC
抗体货号: HZ-11487R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/9/14 11:30:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
传真:
021-31320307
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上海·中国-上海
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产品详细描述

 Rabbit Anti-Slit1/FITC Conjugated antibody

FITC标记的多重表皮生长因子样蛋白4抗体

 

产品编号 bs-11487R-FITC
英文名称 Anti-Slit1/FITC
中文名称 FITC标记的多重表皮生长因子样蛋白4抗体
别    名 MEGF 4; MEGF4; Multiple EGF like domains protein 4; Multiple epidermal growth factor like domains 4; Multiple epidermal growth factor like domains protein 4; SLIL 1; SLIL1; Slit 1; SLIT 3; Slit homolog 1; Slit homolog 1 protein; Slit-1; Slit1; SLIT3; KIAA0813; SLIT1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 164kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Slit1/MEGF4 (455-500aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural development by acting as high-affinity signaling ligands for the repulsive guidance receptor, Roundabout (Robo) (1, 2). Within the developing central nervous system (CNS) of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting a conserved function among vertebrate homologs (3,4). Slit is expressed in the midline of the central nervous system in both vertebrates and invertebrates, where it functions as a regulatory factor of mesodermal cell movement during gastrulation (5). Slit2 is a short range inhibitory guidance cue for retinal ganglion cell (RGC) axons that may mediate spatial progression of RGCs (6,7).

Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

Subunit:
Interacts with ROBO1 and GREM1

Subcellular Location:
Secreted.

Tissue Specificity:
Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.

Similarity:
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 9 EGF-like domains.
Contains 1 laminin G-like domain.
Contains 20 LRR (leucine-rich) repeats.
Contains 4 LRRCT domains.
Contains 4 LRRNT domains.

Database links:

Entrez Gene: 395293 Chicken

Entrez Gene: 6585 Human

Entrez Gene: 20562 Mouse

Entrez Gene: 65047 Rat

Entrez Gene: 380270 Xenopus laevis

Omim: 603742 Human

SwissProt: O75093 Human

SwissProt: Q80TR4 Mouse

SwissProt: O88279 Rat

Unigene: 632082 Human

Unigene: 40322 Mouse

Unigene: 30002 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

分泌的富含亮氨酸重复序列的含蛋白1-3(SLIT1-3)是分泌的糖蛋白,其通过作为排斥引导受体(Rouo)(ROBO)(1, 2)的高亲和信号配体发挥影响轴突导向和介导正常神经发育。在不同脊椎动物系统的发育中枢神经系统(CNS)中,狭缝蛋白在等效区域中表达,提示脊椎动物同源物(3,4)之间具有保守功能。狭缝在脊椎动物和无脊椎动物的中枢神经系统的中线中表达,其中它在原肠胚形成过程中作为中胚层细胞运动的调节因子(5)。SLIT2是视网膜神经节细胞(RGC)轴突的一个短程抑制性指导线索,可介导RGCS(6,7)的空间进展。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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