FITC标记的神经丛蛋白B3抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的神经丛蛋白B3抗体
英文名称: Anti-PLXNB3/FITC
抗体货号: HZ-11470R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 10:09:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:754点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-PLXNB3/FITC Conjugated antibody

FITC标记的神经丛蛋白B3抗体

 

产品编号 bs-11470R-FITC
英文名称 Anti-PLXNB3/FITC
中文名称 FITC标记的神经丛蛋白B3抗体
别    名 Plexin B3; KIAA1206; PLEXB3; Plexin-B3; PLEXR; PLXB3_HUMAN; PLXN6; PLXNB3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 202kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Plexin B2 (354-400aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. They are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Plexin-B1 and -B2 are both receptors for Sema4D, which stimulates axonal outgrowth of embryonic dorsal root ganglion neurons. . Plexin-B3 binds to Sema5A, which controls axon guidance and can initiate the intracellular signaling of the hepatocyte growth factor/scatter factor receptor Met.

Function:
Receptor for SEMA5A. Plays a role in axon guidance, invasive growth and cell migration.

Subunit:
Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain). 

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane. 

Tissue Specificity:
Detected at very low levels in several fetal tissues.

Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.

Database links:

Entrez Gene: 5365 Human

Omim: 300214 Human

SwissProt: Q9ULL4 Human

Unigene: 632833 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

丛蛋白是脊椎动物中多类信号素的一个大跨膜受体家族。它们被广泛表达,其胞外域的区域都是分散因子受体和信号素域的同源物。丛蛋白可单独作为信号素受体或与神经素结合。丛蛋白被分为四个亚家族,即丛蛋白A、-B、-C和-D。丛蛋白B1和-B2都是SEMA4D的受体,刺激胚胎背根神经节神经元轴突生长。丛蛋白B3结合SAMA5A,它控制轴突导向,并能启动肝细胞生长因子/分散因子受体Met的细胞内信号传导。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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