FITC标记的PHD指蛋白21A抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的PHD指蛋白21A抗体
英文名称: Anti-PHF21A/FITC
抗体货号: HZ-11452R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 10:24:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-PHF21A/FITC Conjugated antibody

FITC标记的PHD指蛋白21A抗体

 

产品编号 bs-11452R-FITC
英文名称 Anti-PHF21A/FITC
中文名称 FITC标记的PHD指蛋白21A抗体
别    名 BHC80 / PHF21A; BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35-HDAC complex protein BHC80; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A_HUMAN; PHD finger protein 21A; PHF21A.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  转录调节因子  锌指蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PHF21A (351-450aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]

Function:
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

Subunit:
Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in brain. Expressed at much lower level in other tissues.

Similarity:
Contains 1 A.T hook DNA-binding domain. 
Contains 1 PHD-type zinc finger.

Database links:

Entrez Gene: 51317 Human

Entrez Gene: 192285 Mouse

Entrez Gene: 362166 Rat

SwissProt: Q96BD5 Human

SwissProt: Q6ZPK0 Mouse

Unigene: 502458 Human

Unigene: 330408 Mouse

Unigene: 450689 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

PHF21A基因编码BHC80,BRH80是BRAF35(MIM 605535)/组蛋白去乙酰化酶(HDAC;参见MIM 601241)复合物(BHC)的一个组分,它通过被称为阻遏元件-1(Re1)或神经限制性消音器(NRS)的顺式调控元件介导神经元特异性基因的抑制(Hakimi等,2)。002 [ PubMed 12032298 ])[由OMIM提供,NOV 2010 ]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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