Rabbit Anti-AMIGO2/FITC Conjugated antibody
|别 名||Adhesion molecule with Ig like domain 2; ALI 1; ALI1; Alivin 1; Alivin-1; Alivin1; AMIGO 2; Amphoterin induced gene 2; Amphoterin induced protein 2; DEGA; AMGO2_HUMAN; AMIGO-2; Amigo2; Amphoterin induced protein 2; Amphoterin-induced protein 2; Differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; Transmembrane protein AMIGO 2; Transmembrane protein AMIGO2.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||54kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human AMIGO2|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction.
A novel primary response gene, AMIGO2, is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human AMIGO2 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse AMIGO2 was mapped to a locus approximately 55.3 cm from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Binds itself as well as AMIGO1 and AMIGO3 (By similarity).
Cell membrane; Single-pass type I membrane protein. Nucleus. Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons By
Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
Belongs to the immunoglobulin superfamily. AMIGO family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Entrez Gene: 347902 Human
SwissProt: Q86SJ2 Human
Unigene: 121520 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
两性霉素诱导的基因和ORF（AMIGO）家族的蛋白质由AMIGO-1、AMIGO -2和AMIGO -3组成。所有三个成员是单程I型膜蛋白，含有丰富的亮氨酸重复序列，一个IgG结构域和跨膜结构域。AMYGO蛋白在神经元组织的纤维束上特异性表达，参与它们的形成。AmiGo蛋白可以彼此形成络合物，但也可以结合自身。AmiGO-1，也被命名为Avivin -2，促进神经突起的生长和收缩，并在神经轴突发育的髓鞘化和束状过程中起作用。在小脑神经元中，AMIGO 2（AviI-1）是去极化依赖性生存的关键。与AmiGO-1和AmiGo -2相似，AmiGo -3（Avivin 3）在嗜同种和/或异嗜性细胞-细胞相互作用和信号转导中起作用。