FITC标记的肌动蛋白结合蛋白1抗体
产品名称： FITC标记的肌动蛋白结合蛋白1抗体
英文名称： Anti-ABLIM1/FITC
产品编号： HZ-11449R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-ABLIM1/FITC Conjugated antibody
FITC标记的肌动蛋白结合蛋白1抗体
| 产品编号 | bs-11449R-FITC |
| 英文名称 | Anti-ABLIM1/FITC |
| 中文名称 | FITC标记的肌动蛋白结合蛋白1抗体 |
| 别 名 | ABLIM 1; ABLIM; abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein family member 1; Actin-binding double zinc finger protein; Actin-binding double zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein 1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ABLIM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription. Function: May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. Subunit: Binds F-actin. Interacts with ABRA. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton. Tissue Specificity: Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers. Similarity: Contains 1 HP (headpiece) domain. Contains 4 LIM zinc-binding domains. Database links: Entrez Gene: 3983 Human Entrez Gene: 226251 Mouse Entrez Gene: 307989 Rat Omim: 602330 Human SwissProt: O14639 Human SwissProt: Q8K4G5 Mouse Unigene: 438236 Human Unigene: 538331 Human Unigene: 593868 Human Unigene: 217161 Mouse Unigene: 446592 Mouse Unigene: 40404 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
秀丽线虫蛋白UNC-115通过调节生长锥肌动蛋白细胞骨架介导轴突导向，以响应生长锥受体所接收的信号。UNC-115的哺乳动物同源物是肌动蛋白结合的LIM蛋白家族成员1（ABLIM1，也被指定为Limatin）。ABLIM1蛋白具有N-末端结构域，其包含四个双锌指基序，其符合LIM基序一致序列。ABLIM1通过F-肌动蛋白通过类似Dimin样结构域结合，并在视网膜、脑和肌肉组织中表达。有四种已知的ABLIM1亚型。编码AbMIL1的基因映射到与人类肿瘤中的杂合性丢失频繁相关的第10染色体区域，从而识别ABLIM1作为候选肿瘤抑制基因。ABLIM2和ABLIM3在肌肉和神经元组织中表达最高，与F-肌动蛋白结合，并定位在应激纤维上。他们还显示，增强星级（横纹肌激活的Rho信号）依赖激活的血清反应因子（SRF），从而调节转录。