FITC标记的芳香烃受体核转录蛋白样2抗体上海沪震实业有限公司

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产品名称: FITC标记的芳香烃受体核转录蛋白样2抗体
英文名称: Anti-ARNTL2/FITC
抗体货号: HZ-11446R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/19 14:41:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-ARNTL2/FITC Conjugated antibody

FITC标记的芳香烃受体核转录蛋白样2抗体

 

产品编号 bs-11446R-FITC
英文名称 Anti-ARNTL2/FITC
中文名称 FITC标记的芳香烃受体核转录蛋白样2抗体
别    名 ARNT L2; ARNTL 2; ARNTL2; ARNTL2 protein; Aryl hydrocarbon receptor nuclear translocator like 2; Aryl hydrocarbon receptor nuclear translocator like protein 2; Aryl hydrocarbon receptor nuclear translocator-like 2; Basic helix loop helix PAS protein MOP9; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; BMA L2; BMAL 2; BMAL2; Brain and muscle ARNT like 2; Brain and muscle ARNT-like 2; CLIF; CYCLE like factor; CYCLE-like factor; Member of PAS protein 9; MGC124257; MGC149671; MGC149672; MGC158186; MOP 9; MOP9; PASD 9; PASD9; Transcription factor BMAL 2; Transcription factor BMAL2; wu:fj90c09; BMAL2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ARNTL2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.

Function:
ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2) is a basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor. ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It may participate in circadian clock regulation

Subunit:
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A.

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala. 

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain. 
Contains 1 PAC (PAS-associated C-terminal) domain. 
Contains 2 PAS (PER-ARNT-SIM) domains. 

Database links:

Entrez Gene: 56938 Human

Entrez Gene: 373925 Chicken

SwissProt: Q8QGQ7 Chicken

wissProt: Q8WYA1 Human

Unigene: 434269 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

BMAL2是一个636个氨基酸的蛋白质,定位于细胞核并包含一个BHLH(基本螺旋-环-螺旋)结构域,一个PAC(PAS相关的C-末端)结构域和两个PAS(Per-ARNT-SIM)结构域。在胎盘和脑中的高表达,在肝脏、胸腺、心脏、肺和肾脏中的低水平,BMAL2起着昼夜节律核心振荡器的一部分的作用,它包括串联激活靶基因转录的多种蛋白质。更具体地说,BMAL2在作为核心振荡器的一个组成部分时,与目标DNA的E-box元件(3′-CaCGTG-5′)结合,从而诱导转录。BMAR2的多个异构体由于选择性剪接事件而存在。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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