FITC标记的上皮型钙粘附分子抗体
产品名称： FITC标记的上皮型钙粘附分子抗体
英文名称： Anti-VE Cadherin/FITC
产品编号： HZ-4310R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200
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Rabbit Anti-VE Cadherin/FITC Conjugated antibody
FITC标记的上皮型钙粘附分子抗体
| 产品编号 | bs-4310R-FITC |
| 英文名称 | Anti-VE Cadherin/FITC |
| 中文名称 | FITC标记的上皮型钙粘附分子抗体 |
| 别 名 | VE-cadherin; cadherin-5; VE-Cadherin;Cdh5; Vascular endothelial cadherin; 7B4 antigen; CD144 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; Vascular epithelium cadherin; VE Cad antibody VE-cadherin; VE cadherin; VEC; CADH5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 细胞粘附分子 血管内皮细胞 内皮细胞 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, |
| 产品应用 | Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VE Cadherin (251-320aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Subunit: Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Subcellular Location: Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries. Tissue Specificity: Endothelial tissues and brain. Post-translational modifications: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. Similarity: Contains 5 cadherin domains. Database links: Entrez Gene: 1003 Human Entrez Gene: 12562 Mouse Entrez Gene: 307618 Rat Omim: 601120 Human SwissProt: P33151 Human SwissProt: P55284 Mouse Unigene: 76206 Human Unigene: 21767 Mouse Unigene: 224644 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是钙粘蛋白超家族中的经典钙粘蛋白，位于16号染色体长臂上的六钙粘蛋白簇中，参与乳腺癌和前列腺癌中杂合性事件的丢失。编码的蛋白质是钙依赖的细胞-细胞粘附糖蛋白，由五种胞外钙黏蛋白重复序列、跨膜区和高度保守的胞质尾组成。作为一种典型的钙黏蛋白，通过赋予细胞以亲同种方式粘附的能力，该蛋白可能通过控制细胞间连接的凝聚力和组织在内皮细胞生物学中发挥重要作用。已经描述了一种替代剪接变异体，但其全长序列尚未确定。