Rabbit Anti-SLCO1C1/FITC Conjugated antibody
|别 名||OATP-F; OATP1C1; OATPRP5; organic anion transporter F; organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; SLC21A14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family, member 1C1; SO1C1_HUMAN .|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 神经生物学 通道蛋白 细胞膜蛋白|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||79kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human SLCO1C1/OATP-F 401-500aa|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain.
SLCO1C1 is a member of the organic anion transporter family. SLCO1C1 is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants which produce 5 distinct proteins.
Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain.
Entrez Gene: 518047 Cow
Entrez Gene: 53919 Human
Entrez Gene: 58807 Mouse
Entrez Gene: 84511 Rat
Omim: 613389 Human
SwissProt: Q9NYB5 Human
SwissProt: Q9ERB5 Mouse
SwissProt: Q9EPZ7 Rat
Unigene: 47261 Human
Unigene: 284495 Mouse
Unigene: 45744 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
蛋白质的有机阴离子转运蛋白家族介导肝脏摄取强心苷。OATP F是有机阴离子转运蛋白家族的712氨基酸成员。OATP F是一种多通道膜蛋白，介导甲状腺甲状腺素（T4）、RT3和其他有机阴离子的Na+无关、高亲和力转运。OATP F也被认为能以较低的效率运输3-硫酸雌二醇和磺基溴酞（BSP）、三***甲状腺原氨酸（T3）和17β-葡萄糖醛酸基雌二醇。OATP F在睾丸和脑内的睾丸间质细胞中高表达。