FITC标记的溶质载体家族蛋白21成员1C1抗体上海沪震实业有限公司

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产品名称: FITC标记的溶质载体家族蛋白21成员1C1抗体
英文名称: Anti-SLCO1C1/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/17 14:57:00
详细资料:  实验方法技术资料
浏览人数:27
诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-SLCO1C1/FITC Conjugated antibody

FITC标记的溶质载体家族蛋白21成员1C1抗体

 

产品编号 bs-11436R-FITC
英文名称 Anti-SLCO1C1/FITC
中文名称 FITC标记的溶质载体家族蛋白21成员1C1抗体
别    名 OATP-F; OATP1C1; OATPRP5; organic anion transporter F; organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; SLC21A14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family, member 1C1; SO1C1_HUMAN .  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  通道蛋白  细胞膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 79kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLCO1C1/OATP-F 401-500aa
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain. 

Function:
SLCO1C1 is a member of the organic anion transporter family. SLCO1C1 is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants which produce 5 distinct proteins.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus

Tissue Specificity:
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.

Similarity:
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain. 

Database links:

Entrez Gene: 518047 Cow

Entrez Gene: 53919 Human

Entrez Gene: 58807 Mouse

Entrez Gene: 84511 Rat

Omim: 613389 Human

SwissProt: Q9NYB5 Human

SwissProt: Q9ERB5 Mouse

SwissProt: Q9EPZ7 Rat

Unigene: 47261 Human

Unigene: 284495 Mouse

Unigene: 45744 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

蛋白质的有机阴离子转运蛋白家族介导肝脏摄取强心苷。OATP F是有机阴离子转运蛋白家族的712氨基酸成员。OATP F是一种多通道膜蛋白,介导甲状腺甲状腺素(T4)、RT3和其他有机阴离子的Na+无关、高亲和力转运。OATP F也被认为能以较低的效率运输3-硫酸雌二醇和磺基溴酞(BSP)、三***甲状腺原氨酸(T3)和17β-葡萄糖醛酸基雌二醇。OATP F在睾丸和脑内的睾丸间质细胞中高表达。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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