FITC标记的黑素皮质素4受体抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的黑素皮质素4受体抗体
英文名称: Anti-MC4 Receptor/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 11:13:00
详细资料:  实验方法技术资料
浏览人数:13
诚信指数:754点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-MC4 Receptor/FITC Conjugated antibody 

FITC标记的黑素皮质素4受体抗体

 

产品编号 bs-11417R-FITC
英文名称 Anti-MC4 Receptor/FITC
中文名称 FITC标记的黑素皮质素4受体抗体
别    名 MC4 R; MC4-R; MC4R; MC4R_HUMAN; Melanocortin 4 receptor; Melanocortin receptor 4; MGC126851; MGC138197.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  神经生物学  信号转导  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MC4 Receptor (1-50aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The melanocortin family comprises the Alpha-, Beta- and Gamma- melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues.

Function:
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.

Subunit:
Interacts with ATRNL1. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. 

Subcellular Location:
Cell membrane; Multi-pass membrane protein. 

Tissue Specificity:
Brain, placental, and gut tissues.

DISEASE:
Defects in MC4R are a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 4160 Human

Entrez Gene: 17202 Mouse

Entrez Gene: 25635 Rat

Omim: 155541 Human

SwissProt: P32245 Human

SwissProt: P56450 Mouse

SwissProt: P70596 Rat

Unigene: 532833 Human

Unigene: 229447 Mouse

Unigene: 10620 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

melanocortin家族包括α-、β-和γ-黑素细胞刺激(MSH)和促肾上腺皮质。这些的受体是七个跨膜G蛋白偶联蛋白,激活腺苷酸环化酶。五个黑皮质素受体已被克隆,并表现出不同的亲和力和表达模式。MC1-R(MSH-R)在黑素细胞和肾上腺皮质组织中表达。MC2-R是ACTH受体,主要表达于肾上腺皮质。MC3-R已被发现在脑的特定区域,并在胎盘和肠中也表达。MC4-R主要在脑中表达,而MC5-R在大多数组织中表达水平较低。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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