FITC标记的白细胞介素28受体抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的白细胞介素28受体抗体
英文名称: Anti-IL-28R/FITC
抗体货号: HZ-11137R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 11:44:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:754点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-IL-28R/FITC Conjugated antibody

FITC标记的白细胞介素28受体抗体

 

产品编号 bs-11137R-FITC
英文名称 Anti-IL-28R/FITC
中文名称 FITC标记的白细胞介素28受体抗体
别    名 Alternative namesIFNLR; Class II cytokine receptor CRF2/12; CRF2/12; Cytokine receptor family 2 member 12; IFN lambda R1; IFNLR1; il-28r1; IL28R alpha; Interferon lambda receptor 1; Interferon lambda receptor; Interleukin 28 receptor alpha chain; LICR2; Likely interleukin or cytokine receptor 2.I28RA_HUMAN   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-28R
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway.

Function:
IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.

Subunit:
Heterodimer with IL10RB.

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the type II cytokine receptor family.
Contains 1 fibronectin type-III domain. 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

IL-28 R是由人类基因IL28 Ra编码的535氨基酸蛋白。IL-28 R属于II型细胞因子受体家族,包含1个纤连蛋白Ⅲ型结构域。它是一种单通道I型膜蛋白,被发现为具有IL-10Rb的异源二聚体。这是一个小家族的结构相关的细胞因子受体,如IFNs,已知诱导抗病毒活性。IFN-Ⅰ(IL-28)mRNA的表达可通过多种细胞系的病毒感染诱导。由所有三个IFN-L蛋白用于信号转导的受体复合物(IL-28 R)由两个亚基组成,一个受体指定IL-28 R和IL-10R2。这两个受体链在多种人类细胞系和组织上组成性表达,并通过JAK STAT(JANUS激酶信号转导子和转录激活子)途径进行信号转导。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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