Rabbit Anti-IL-28R/FITC Conjugated antibody
|别 名||Alternative namesIFNLR; Class II cytokine receptor CRF2/12; CRF2/12; Cytokine receptor family 2 member 12; IFN lambda R1; IFNLR1; il-28r1; IL28R alpha; Interferon lambda receptor 1; Interferon lambda receptor; Interleukin 28 receptor alpha chain; LICR2; Likely interleukin or cytokine receptor 2.I28RA_HUMAN|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 免疫学 G蛋白偶联受体 G蛋白信号|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||55kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human IL-28R|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway.
IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.
Heterodimer with IL10RB.
Membrane; Single-pass type I membrane protein
Belongs to the type II cytokine receptor family.
Contains 1 fibronectin type-III domain.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
IL-28 R是由人类基因IL28 Ra编码的535氨基酸蛋白。IL-28 R属于II型细胞因子受体家族，包含1个纤连蛋白Ⅲ型结构域。它是一种单通道I型膜蛋白，被发现为具有IL-10Rb的异源二聚体。这是一个小家族的结构相关的细胞因子受体，如IFNs，已知诱导抗病毒活性。IFN-Ⅰ（IL-28）mRNA的表达可通过多种细胞系的病毒感染诱导。由所有三个IFN-L蛋白用于信号转导的受体复合物（IL-28 R）由两个亚基组成，一个受体指定IL-28 R和IL-10R2。这两个受体链在多种人类细胞系和组织上组成性表达，并通过JAK STAT（JANUS激酶信号转导子和转录激活子）途径进行信号转导。