FITC标记的白细胞介素28受体抗体
产品名称: FITC标记的白细胞介素28受体抗体
英文名称: Anti-IL-28R/FITC
产品编号: HZ-11137R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-IL-28R/FITC Conjugated antibody
FITC标记的白细胞介素28受体抗体
产品编号 | bs-11137R-FITC |
英文名称 | Anti-IL-28R/FITC |
中文名称 | FITC标记的白细胞介素28受体抗体 |
别 名 | Alternative namesIFNLR; Class II cytokine receptor CRF2/12; CRF2/12; Cytokine receptor family 2 member 12; IFN lambda R1; IFNLR1; il-28r1; IL28R alpha; Interferon lambda receptor 1; Interferon lambda receptor; Interleukin 28 receptor alpha chain; LICR2; Likely interleukin or cytokine receptor 2.I28RA_HUMAN |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 免疫学 G蛋白偶联受体 G蛋白信号 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 55kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human IL-28R |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway. Function: IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain. Subunit: Heterodimer with IL10RB. Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Widely expressed. Similarity: Belongs to the type II cytokine receptor family. Contains 1 fibronectin type-III domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
IL-28 R是由人类基因IL28 Ra编码的535氨基酸蛋白。IL-28 R属于II型细胞因子受体家族,包含1个纤连蛋白Ⅲ型结构域。它是一种单通道I型膜蛋白,被发现为具有IL-10Rb的异源二聚体。这是一个小家族的结构相关的细胞因子受体,如IFNs,已知诱导抗病毒活性。IFN-Ⅰ(IL-28)mRNA的表达可通过多种细胞系的病毒感染诱导。由所有三个IFN-L蛋白用于信号转导的受体复合物(IL-28 R)由两个亚基组成,一个受体指定IL-28 R和IL-10R2。这两个受体链在多种人类细胞系和组织上组成性表达,并通过JAK STAT(JANUS激酶信号转导子和转录激活子)途径进行信号转导。