FITC标记的钙激活钾通道蛋白4抗体上海沪震实业有限公司

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产品名称: FITC标记的钙激活钾通道蛋白4抗体
英文名称: Anti-KCNN4/FITC
抗体货号: HZ-6675R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/12 10:52:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-KCNN4/FITC Conjugated antibody

FITC标记的钙激活钾通道蛋白4抗体

 

英文名称 Anti-KCNN4/FITC
中文名称 FITC标记的钙激活钾通道蛋白4抗体
别    名 hIKCa1; IK1; IKCa1; Intermediate conductance calcium activated potassium channel protein 4; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; Kcnn4; KCNN4_HUMAN; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4; Putative Gardos channel; SK4; SKCa 4; SKCa4.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  通道蛋白  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNN4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Subunit:
Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6. 

Subcellular Location:
Membrane; Multi-pass membrane protein. 

Tissue Specificity:
Widely expressed in non-excitable tissues. 

Post-translational modifications:
Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. 

Similarity:
Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. 

Database links:

Entrez Gene: 3783 Human

Entrez Gene: 16534 Mouse

Entrez Gene: 65206 Rat

Omim: 602754 Human

SwissProt: O15554 Human

SwissProt: O89109 Mouse

SwissProt: Q9QYW1 Rat

Unigene: 10082 Human

Unigene: 9911 Mouse

Unigene: 44212 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

形成由细胞内钙激活的与电压无关的钾通道。激活后膜超极化,促进钙内流。在幼稚T细胞的再活化过程中需要最大的钙内流和增殖。通道被克霉唑和Cabydodo毒素阻断,但对APAMIN不敏感。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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