FITC标记的DNA结合抑制因子4抗体上海沪震实业有限公司

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产品名称: FITC标记的DNA结合抑制因子4抗体
英文名称: Anti-ID4/FITC
抗体货号: HZ-6669R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/15 12:29:00
详细资料:  实验方法技术资料
浏览人数:15
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ID4/FITC Conjugated antibody

FITC标记的DNA结合抑制因子4抗体

 

英文名称 Anti-ID4/FITC
中文名称 FITC标记的DNA结合抑制因子4抗体
别    名 bHLHb27; Class B basic helix-loop-helix protein 27; DNA binding protein inhibitor ID 4; DNA binding protein inhibitor ID4; DNA-binding protein inhibitor ID-4; ID 4; Id4; ID4_HUMAN; IDB4; Inhibitor of DNA binding 4; Inhibitor of DNA binding 4 dominant negative helix loop helix protein.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  干细胞  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ID4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (1–3), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (1–5). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Function:
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 3400 Human

Entrez Gene: 15904 Mouse

Entrez Gene: 291023 Rat

Omim: 600581 Human

SwissProt: P47928 Human

SwissProt: P41139 Mouse

SwissProt: Q06AV5 Pig

Unigene: 519601 Human

Unigene: 458006 Mouse

Unigene: 22987 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

Id家族的基本螺旋-环-螺旋(BHLH)蛋白的成员包括ID1(1 - 3)、ID2(4)、ID3和ID4(5)。它们与A和B类HLH蛋白(1 - 5)的成员一起被广泛表达和二聚。由于缺乏基本区域,所得异源二聚体不能结合DNA。因此,ID型蛋白质似乎负调控BHLH蛋白的DNA结合。由于ID1抑制E12和Myo D的DNA结合,它显然起到抑制肌肉特异性基因表达的作用。在促进肌肉细胞分化的条件下,Id蛋白水平下降,使E12和/或E47形成异源二聚体与肌组织和肌生成素,这反过来又激活肌源性分化。已经表明,每个ID蛋白的表达强烈依赖于生长因子的激活,并且通过反义寡核苷酸降低IDmRNA水平导致在生长因子刺激后被阻滞细胞延迟进入细胞周期的再入。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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