FITC标记的同源盒蛋白HOXA11抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的同源盒蛋白HOXA11抗体
英文名称: Anti-HOXA11/FITC
抗体货号: HZ-6666R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/12 11:10:00
详细资料:  实验方法技术资料
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诚信指数:783点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-HOXA11/FITC Conjugated antibody

FITC标记的同源盒蛋白HOXA11抗体

 

英文名称 Anti-HOXA11/FITC
中文名称 FITC标记的同源盒蛋白HOXA11抗体
别    名 HXA11_HUMAN; Hox 1I; Homeo box 1I; Homeo box A11; Homeobox A11; Homeobox protein Hox-A11; Homeobox protein HOXA11; Hox-1I; HOX1; HOX1I.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HOXA11
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.

Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Location:
Nuclear

DISEASE:
Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT) [MIM:605432]. The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. 

Similarity:
Belongs to the Abd-B homeobox family.
Contains 1 homeobox DNA-binding domain. 

Database links:

Entrez Gene: 3207 Human

Entrez Gene: 15396 Mouse

Omim: 142958 Human

SwissProt: P31270 Human

SwissProt: P31311 Mouse

SwissProt: Q3V026 Mouse

Unigene: 249171 Human

Unigene: 26954 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

在脊椎动物中,编码称为同源框基因的一类转录因子的基因被发现在A、B、C和D的四个染色体上。在胚胎发育过程中,这些蛋白质的表达在空间和时间上受到调节。该基因是7号染色体上的一个簇的一部分,编码一个可以调节基因表达、形态发生和分化的DNA结合转录因子。该基因参与子宫发育的调节,对女性生育能力是必需的。该基因的突变可导致桡骨尺侧骨性关节炎合并巨核细胞性血小板减少症。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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