FITC标记的脑环核苷酸门控通道蛋白1/HCN1抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的脑环核苷酸门控通道蛋白1/HCN1抗体
英文名称: Anti-BCNG1/FITC
抗体货号: HZ-6604R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/13 10:03:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
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021-31320307
联系人:
陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-BCNG1/FITC Conjugated antibody 

FITC标记的脑环核苷酸门控通道蛋白1/HCN1抗体

 

英文名称 Anti-BCNG1/FITC
中文名称 FITC标记的脑环核苷酸门控通道蛋白1/HCN1抗体
别    名 HCN1; BCNG1; Brain cyclic nucleotide gated channel 1; HAC2; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  神经生物学  通道蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BCNG1/HCN1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Hyperpolarization activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarisation and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.

Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli.

Subunit:
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Predominantly expressed in brain. Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum. Expressed in a subset of elongated cells in taste buds.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the immunoglobulin superfamily. ICAM family.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.

Database links:

UniProtKB/Swiss-Prot: O88704.1



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

HCN基因家族如HCN1的超极化激活的阳离子通道,有助于心脏和脑的自发节律活动。HCN1是由超极化激活并由环核苷酸调节的起搏器通道家族的成员。HCN1和HCN2在小脑浦肯野细胞的运动学习和神经元整合中发挥重要作用,以及形成单个神经元的自主活动和网络振荡的周期性。HCN1表达在大脑皮质、海马、小脑和面运动核中高度富集。HCN2在乳头体、桥脑核、腹侧耳蜗核和梯形体核中高度丰富。HCN通道的区域特异性的这些变化可能在脑系统中产生神经元起搏器活动的重要差异。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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