FITC标记的整合素样金属蛋白酶与凝血酶10型抗体上海沪震实业有限公司

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产品名称: FITC标记的整合素样金属蛋白酶与凝血酶10型抗体
英文名称: Anti-ADAMTS10/FITC
抗体货号: HZ-6588R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/9/9 14:22:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ADAMTS10/FITC Conjugated antibody

FITC标记的整合素样金属蛋白酶与凝血酶10型抗体

 

英文名称 Anti-ADAMTS10/FITC
中文名称 FITC标记的整合素样金属蛋白酶与凝血酶10型抗体
别    名 A disintegrin and metalloproteinase with thrombospondin motifs 10; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; ADAM metallopeptidase with thrombospondin type 1 motif 10; ADAM TS10; EC 3.4.24; WMS; ATS10_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADAMTS10
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53% overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines.

Function:
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. 

Subunit:
Interacts with FBN1; this interaction promotes microfibrils assembly. 

Subcellular Location:
Secreted, extracellular space, extracellular matrix. 

Tissue Specificity:
Widely expressed in adult tissues. 

Post-translational modifications:
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). 

DISEASE:
Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1) [MIM:277600]. WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. 

Similarity:
Contains 1 disintegrin domain. 
Contains 1 peptidase M12B domain. 
Contains 1 PLAC domain. 
Contains 5 TSP type-1 domains. 

Database links:

Entrez Gene: 81794 Human

Entrez Gene: 224697 Mouse

Entrez Gene: 314655 Rat

Omim: 608990 Human

SwissProt: Q9H324 Human

SwissProt: P58459 Mouse

Unigene: 657508 Human

Unigene: 29304 Mouse

Unigene: 135600 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

ADAMTS10是亚当斯家族的一个成员,具有凝血酶敏感蛋白基序。ADAMTS10的催化位点是典型的金属蛋白酶催化结构域,具有HxXHXXXXH序列,可能给予这些酶一些共同的特异性。ADAMTS10与ADAMTS6同源性最高,共有53%个整体身份。ADAMTS10的功能性突变与Weill Marchesani综合征有关,它是一种以纤维蛋白1错误处理为标志的结缔组织疾病。ADAMTS10也被报道在乳腺癌组织和细胞系中过表达。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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