Rabbit Anti-PAI1/FITC Conjugated antibody
|别 名||Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serpin E1; Serpin peptidase inhibitor clade E; Serpine 1; Serpine-1;Serpine1.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 心血管 细胞生物 激酶和***酸酶 肿瘤细胞生物标志物|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||45kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human PAI1/PLANH1|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.
Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) . It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
Belongs to the serpin family.
Entrez Gene: 5054 Human
Entrez Gene: 18787 Mouse
Entrez Gene: 24617 Rat
Omim: 173360 Human
SwissProt: P05121 Human
SwissProt: P22777 Mouse
SwissProt: P20961 Rat
Unigene: 414795 Human
Unigene: 713079 Human
Unigene: 250422 Mouse
Unigene: 29367 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications