FITC标记的组蛋白赖氨酸N-甲基EZH1抗体上海沪震实业有限公司

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产品名称: FITC标记的组蛋白赖氨酸N-甲基EZH1抗体
英文名称: Anti-EZH1/FITC
抗体货号: HZ-6528R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/25 12:46:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-EZH1/FITC Conjugated antibody

FITC标记的组蛋白赖氨酸N-甲基EZH1抗体

 

英文名称 Anti-EZH1/FITC
中文名称 FITC标记的组蛋白赖氨酸N-甲基EZH1抗体
别    名 Enhancer of zeste homolog 1(Drosophila); Enhancer of zeste homolog 1; ENX-2; ENX2; EZH1; EZH1: enhancer of zeste homolog 1 (Drosophila); EZH1_HUMAN; Histone-lysine N-methyltransferase EZH1; KIAA0388.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  染色质和核信号  肿瘤细胞生物标志物  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EZH1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Sequence similarities 
Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 SET domain.

Function:
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Subunit:
Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM).

Subcellular Location:
Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.

Similarity:
Belongs to the histone-lysine methyltransferase family. EZ subfamily.
Contains 1 CXC domain. 
Contains 1 SET domain.

Database links:

Entrez Gene: 2145 Human

Entrez Gene: 14055 Mouse

Entrez Gene: 303547 Rat

Omim: 601674 Human

SwissProt: Q92800 Human

SwissProt: P70351 Mouse

Unigene: 194669 Human

Unigene: 5027 Mouse

Unigene: 154549 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

多梳组蛋白(PCG)。PRC2/ED-EZH1复合物的催化亚基,其甲基化了组蛋白H3的“LYS-27”,导致受影响的靶基因的转录抑制。能够将组蛋白H3的单、二和三甲基酯“LYS-27”分别形成H3K27 ME1、H3K27 ME2和H3K27 ME3。胚胎干细胞的衍生和自我更新所需要的,这表明它参与了胚胎干细胞身份的保护。与含EZH1的复合物相比,胚胎干细胞中的甲基转移酶活性较低,在形成H3K27 ME3中起着不太重要的作用,这是胚胎干细胞的身份和正确分化所必需的。

序列相似性

 

属于组蛋白赖氨酸甲基转移酶家族。EZ亚家族。包含1个集合域。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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