FITC标记的非受体型酪氨酸蛋白激酶Tnk1抗体上海沪震实业有限公司

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产品名称: FITC标记的非受体型酪氨酸蛋白激酶Tnk1抗体
英文名称: Anti-TNK1/FITC
抗体货号: HZ-3587R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 10:04:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-TNK1/FITC Conjugated antibody

FITC标记的非受体型酪氨酸蛋白激酶Tnk1抗体

 

英文名称 Anti-TNK1/FITC
中文名称 FITC标记的非受体型酪氨酸蛋白激酶Tnk1抗体
别    名 CD38 negative kinase 1; EC 2.7.10.2 antibody Kinase of embryonic stem cells; Kos 1; Kos1; MGC46193; Non receptor tyrosine protein kinase TNK 1; Non receptor tyrosine protein kinase TNK1; Tnk 1; Tyrosine kinase non receptor 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNK1(603-652aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Function:
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Subunit:
Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity:
Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.

Post-translational modifications:
Autophosphorylated on tyrosine residues.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Contains 1 protein kinase domain. 
Contains 1 SH3 domain.

Database links:

Entrez Gene: 8711 Human

Omim: 608076 Human

SwissProt: Q13470 Human

Unigene: 203420 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

TNK1是非受体蛋白酪氨酸激酶(NRPTK),是NRTPK家族Ack家族的新成员。TNK1是一种在胚胎发育过程中发育调控的具有自我酪氨酸激酶活性的47 kDa蛋白。TNL1也上调IL3撤回因子依赖的小鼠NSF/N1.H7细胞发生凋亡,这表明在生长抑制中的作用。数据支持TNK1通过调节其自身酪氨酸激酶活性的机制在调节RAS-RAF1-MAPK生长途径中的负调控作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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