FITC标记的调节染色体组装激酶1抗体上海沪震实业有限公司

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产品名称: FITC标记的调节染色体组装激酶1抗体
英文名称: Anti-TLK1/FITC
抗体货号: HZ-3583R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 10:33:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-TLK1/FITC Conjugated antibody

FITC标记的调节染色体组装激酶1抗体

 

英文名称 Anti-TLK1/FITC
中文名称 FITC标记的调节染色体组装激酶1抗体
别    名 PKU beta; serine threonine protein kinase; Serine/threonine protein kinase tousled like 1; TLK1; Tousled like kinase 1; TLK1_HUMAN; Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1; KIAA0137.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  染色质和核信号  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLK1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Function:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Subunit:
Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 9874 Human

Entrez Gene: 228012 Mouse

Omim: 608438 Human

SwissProt: Q9UKI8 Human

SwissProt: Q8C0V0 Mouse

Unigene: 726093 Human

Unigene: 731668 Human

Unigene: 136511 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

由该基因编码的蛋白是丝氨酸/苏氨酸激酶,其可能参与染色质组装的调节。编码的蛋白质只有在***酸化时才是活性的,并且这种***酸化是依赖于细胞周期的,在S期中这种蛋白质的最大活性出现。这种蛋白质的催化活性由于DNA损伤和DNA复制的阻断而减弱。已经发现了三个编码不同亚型的转录本变体。[ RefSeq,2011月11日]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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