FITC标记的磷酸化核糖体蛋白S6激酶家族RSK3抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的磷酸化核糖体蛋白S6激酶家族RSK3抗体
英文名称: Anti-Phospho-RSK3 (Thr353 + Thr356)/FITC
抗体货号: HZ-3365R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 13:36:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-Phospho-RSK3 (Thr353 + Thr356)/FITC Conjugated antibody

FITC标记的***酸化核糖体蛋白S6激酶家族RSK3抗体

 

英文名称 Anti-Phospho-RSK3 (Thr353 + Thr356)/FITC
中文名称 FITC标记的***酸化核糖体蛋白S6激酶家族RSK3抗体
别    名 RSK3 (Phospho T353 + T356); Phospho-RSK3 (Thr353 + Thr356); 90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90RSK 2; p90RSK2; pp90RSK 3; pp90RSK3; Ribosomal protein S6 kinase alpha-2; Ribosomal S6 kinase 3; RPS6KA2; RSK 3; RSK-3; S6K alpha 2; S6K alpha; S6K-alpha-2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Guinea Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human RSK3 around the phosphorylation site of Thr353/356
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
RSK3(Ribosomal S6 kinase 3)is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.

Function:
Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells.

Subunit:
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 inquiescent cells. Transiently dissociates following mitogenicstimulation.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Widely expressed with higher expression inlung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.

Post-translational modifications:
Activated by phosphorylation at Ser-218 by PDPK1.Autophosphorylated on Ser-377, as part of the activation process.May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 andMAPK3/ERK1. 
N-terminal myristoylation results in an activated kinase inthe absence of added growth factors. 

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. S6 kinase subfamily. 
Contains 1 AGC-kinase C-terminal domain.
Contains 2 protein kinase domains. 

Database links:

Entrez Gene: 6196 Human

Entrez Gene: 20112 Mouse

Entrez Gene: 117269 Rat

Omim: 601685 Human

SwissProt: Q15349 Human

SwissProt: Q9WUT3 Mouse

Unigene: 655277 Human

Unigene: 268383 Mouse

Unigene: 2356 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

RSK3(核糖体S6激酶3)是90 kDa核糖体蛋白S6激酶家族的成员,其包括RSK1、RSK2和RSK3。这些是广泛表达的丝氨酸/苏氨酸蛋白激酶,其响应于有丝分裂刺激而激活,包括细胞外信号调节蛋白激酶ERK1和ERK2。RSK3是一种不同的p90RSK亚型,它转移到细胞核,***酸化潜在的核靶标,并可能具有独特的上游激活剂。几个位点,如Ser380、Trs359、Ser363和TrHs3 3,对于其活化是重要的。活性RSK在转录调控中发挥重要作用,通过转位到细胞核和***酸化C Fos和CREB。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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