Rabbit Anti-RSK3/FITC Conjugated antibody
|别 名||90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90RSK 2; p90RSK2; pp90RSK 3; pp90RSK3; Ribosomal protein S6 kinase alpha-2; Ribosomal S6 kinase 3; RPS6KA2; RSK 3; RSK-3; S6K alpha 2; S6K alpha; S6K-alpha-2.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat, Dog, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||83kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human RSK3/Ribosomal S6 kinase 3|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
RSK3(Ribosomal S6 kinase 3)is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells.
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 inquiescent cells. Transiently dissociates following mitogenicstimulation.
Widely expressed with higher expression inlung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Activated by phosphorylation at Ser-218 by PDPK1.Autophosphorylated on Ser-377, as part of the activation process.May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 andMAPK3/ERK1.
N-terminal myristoylation results in an activated kinase inthe absence of added growth factors.
Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. S6 kinase subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 2 protein kinase domains.
Entrez Gene: 6196 Human
Entrez Gene: 20112 Mouse
Entrez Gene: 117269 Rat
Omim: 601685 Human
SwissProt: Q15349 Human
SwissProt: Q9WUT3 Mouse
Unigene: 655277 Human
Unigene: 268383 Mouse
Unigene: 2356 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
RSK3（核糖体S6激酶3）是90 kDa核糖体蛋白S6激酶家族的成员，其包括RSK1、RSK2和RSK3。这些是广泛表达的丝氨酸/苏氨酸蛋白激酶，其响应于有丝分裂刺激而激活，包括细胞外信号调节蛋白激酶ERK1和ERK2。RSK3是一种不同的p90RSK亚型，它转移到细胞核，***酸化潜在的核靶标，并可能具有独特的上游激活剂。几个位点，如Ser380、Trs359、Ser363和TrHs3 3，对于其活化是重要的。活性RSK在转录调控中发挥重要作用，通过转位到细胞核和***酸化C Fos和CREB。