FITC标记的磷酸化肽基脯氨酞顺反异构酶Pinl抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化肽基脯氨酞顺反异构酶Pinl抗体
英文名称: Anti-Phospho-Pin1 (Ser16)/FITC
抗体货号: HZ-3354R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 13:54:00
详细资料:  实验方法技术资料
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诚信指数:832点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-Pin1 (Ser16)/FITC Conjugated antibody 

FITC标记的***酸化肽基脯氨酞顺反异构酶Pinl抗体

 

英文名称 Anti-Phospho-Pin1 (Ser16)/FITC
中文名称 FITC标记的***酸化肽基脯氨酞顺反异构酶Pinl抗体
别    名 DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis/trans isomerase NIMA interacting; Pin 1; PPIase Pin1; Prolyl isomerase; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1; Protein NIMA interacting 1; Rotamase Pin1; UBL 5; UBL5; PIN1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  神经生物学  信号转导  干细胞  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Pin1 around the phosphorylation site of Ser16
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

Function:
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.

Subunit:
Interacts with STIL (By similarity). Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX. Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1.

Subcellular Location:
Nucleus. Nucleus speckle. Cytoplasm.

Tissue Specificity:
The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation.

Similarity:
Contains 1 PpiC domain.
Contains 1 WW domain. 

Database links:

Entrez Gene: 5300 Human

Entrez Gene: 23988 Mouse

Entrez Gene: 298696 Rat

Omim: 601052 Human

SwissProt: Q13526 Human

SwissProt: Q9QUR7 Mouse

Unigene: 465849 Human

Unigene: 7906 Mouse

Unigene: 6291 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

肽基脯氨酞顺反异构酶Pinl,是调节细胞有丝分裂相关蛋白酶,对细胞周期运行起着非常重要的调控作用。近年来研究表明,肽基脯氨酞顺反异构酶Pinl在多种肿瘤中过表达,是多个致癌信号通路的关键效应分子,可加强和催化多种致癌信号,使其无限放大,最终引起细胞转化和增殖失控。因次,肽基脯氨酞顺反异构酶Pinl越来越引起人们关注,被称为肿瘤发生发展的催化分子。近来该蛋白用于老年痴呆研究的也日渐增多
   

Pin 1是肽基脯氨酰异构酶(PPIASE)。肽基脯氨酰异构酶(PPIASE)促进肽基脯氨酰键的顺式互转化,从而影响蛋白质折叠。Pin 1是一种特异性识别***酸化S/T-P键的pPIX酶。Pin 1参与了阿尔茨海默病的tau病理学。PU1结合Tau特异性地在THR23 1 Pro位点***酸化,并诱导tau的构象变化。这样的构象变化可以直接恢复***酸化tau结合微管的能力,并促进微管组装和/或促进tau去***酸化。PN1表达与正常老年脑的预测神经元易感性呈负相关,也与AD脑中的实际神经纤维变性有关。PN1可能是维持正常神经元功能和预防年龄依赖性神经退行性变的关键。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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