FITC标记的磷酸化磷酯酶Cγ2抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化磷酯酶Cγ2抗体
英文名称: Anti-Phospho-PLCG 2 (Tyr1217)/FITC
抗体货号: HZ-3338R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 IF=1:50-200
更新时间: 2018/9/5 15:23:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:1084点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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电话:
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陈先生
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产品详细描述

 Rabbit Anti-Phospho-PLCG 2 (Tyr1217)/FITC Conjugated antibody

FITC标记的***酸化***酯酶Cγ2抗体

 

英文名称 Anti-Phospho-PLCG 2 (Tyr1217)/FITC
中文名称 FITC标记的***酸化***酯酶Cγ2抗体
别    名 PLCG 2 (phospho Y1217); p-PLCG 2 (phospho Y1217); PLCG2(phospho Y1217); Phospho-PLC γ2(Tyr1217); Phospho-PLC gamma 2/PLCG2(Tyr1217); PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; EC 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C gamma 2; Phospholipase C, gamma 2 (phosphatidylinositol specific); PLCG2_HUMAN.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  免疫学  信号转导  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PLC gamma 2 around the phosphorylation site of Tyr1217
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide specific phospholipase C enzymes, C beta is regulated by heterotrimeric G protein coupled receptors, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases. The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. 

Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Subunit:
Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity).

Post-translational modifications:
Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.

Similarity:
Contains 1 C2 domain. 
Contains 1 PH domain. 
Contains 1 PI-PLC X-box domain. 
Contains 1 PI-PLC Y-box domain. 
Contains 2 SH2 domains. 
Contains 1 SH3 domain.

Database links:

Entrez Gene: 5336 Human

Entrez Gene: 234779 Mouse

Entrez Gene: 29337 Rat

Omim: 600220 Human

SwissProt: P16885 Human

SwissProt: Q8CIH5 Mouse

SwissProt: P24135 Rat

Unigene: 413111 Human

Unigene: 192699 Mouse

Unigene: 9751 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

***脂酶C家族的酶催化***脂水解以产生脂头基团的二酰甘油和水溶性***酸化衍生物。许多这些酶对***酸肌醇具有特异性。在肌醇***脂特异性***脂酶C酶中,Cβ受异三聚体G蛋白偶联受体调节,而紧密相关的Cγ1和Cγ2酶由受体酪氨酸激酶控制。Cγ1和Cγ2酶由***脂酶结构域组成,侧翼区域与Src癌基因产物SH2和SH3的非催化结构域同源。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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