FITC标记的星形胶质细胞PEA15抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的星形胶质细胞PEA15抗体
英文名称: Anti-PEA15/FITC
抗体货号: HZ-3524R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 9:11:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:832点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
在线QQ: 我是2043711056,请问我有什么可以帮到您呢?
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
邮件:
公司展台:
在线QQ:
我是2043711056,请问我有什么可以帮到您呢?
扫一扫,关注我们

产品详细描述

 Rabbit Anti-PEA15/FITC Conjugated antibody 

FITC标记的星形胶质细胞PEA15抗体

 

英文名称 Anti-PEA15/FITC
中文名称 FITC标记的星形胶质细胞PEA15抗体
别    名 Astrocytic phosphoprotein PEA 15; Astrocytic phosphoprotein PEA15; HMAT 1; HMAT1; Homolog of mouse MAT 1 oncogene; Homolog of mouse MAT1 oncogene; HUMMAT 1H; HUMMAT1H; MAT 1; MAT 1H; MAT1; MAT1H; PEA 15; PEA-15; PEA15 protein; PED; Phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes 15kD; Phosphoprotein enriched in diabetes; PEA15_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  神经生物学  生长因子和***  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PEA15
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function.

Function:
Blocks Ras-mediated inhibition of integrin activationand modulates the ERK MAP kinase cascade. Inhibits RPS6KA3activities by retaining it in the cytoplasm (By similarity).Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity andapoptosis. Regulates glucose transport by controlling both thecontent of SLC2A1 glucose transporters on the plasma membrane andthe insulin-dependent trafficking of SLC2A4 from the cell interiorto the surface.

Subunit:
Binds RPS6KA3, MAPK3 and MAPK1. Transient interactionwith PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD. 

Subcellular Location:
Cytoplasm. Note=Associated withmicrotubules. 

Tissue Specificity:
Ubiquitously expressed. Most abundant intissues such as heart, brain, muscle and adipose tissue whichutilize glucose as an energy source. Lower expression inglucose-producing tissues. Higher levels of expression are found intissues from individuals with type 2 diabetes than in controls.

Post-translational modifications:
Phosphorylated by protein kinase C andcalcium-calmodulin-dependent protein kinase. These phosphorylationevents are modulated by neurotransmitters or hormones.

Similarity:
Contains 1 DED (death effector) domain. 

Database links:

Entrez Gene: 8682 Human

Entrez Gene: 18611 Mouse

Omim: 603434 Human

SwissProt: Q15121 Human

SwissProt: Q62048 Mouse

Unigene: 517216 Human

Unigene: 544 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

PED/PEA 15(富含糖尿病的星形胶质蛋白/富含星形胶质细胞的***酸化蛋白15 kDa)是一种广泛表达的15 kDa蛋白,由包含典型死亡效应域(DE)序列和核输出信号的N末端区域和含有两个丝氨酸的C末端区域组成。***酸化位点。PED/PEA 15参与了多种细胞过程的调节,包括细胞凋亡、整合素激活和胰岛素敏感细胞中的胰岛素敏感葡萄糖转运。丝氨酸104(蛋白激酶C位点)和丝氨酸116(CAMKII和AKT的底物)的***酸化对于PED/PEA 15功能是必需的。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看FITC标记的星形胶质细胞PEA15抗体产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要