Rabbit Anti-Phospho-PKMYT1 (Ser83)/FITC Conjugated antibody
|别 名||Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Myt1 kinase; PMYT1_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 免疫学 神经生物学 信号转导 细胞凋亡 转录调节因子|
|交叉反应||Human, Mouse, Rat, Horse,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||54kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human PKMYT1 around the phosphorylation site of Ser83|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Contains 1 protein kinase domain.
Entrez Gene: 9088 Human
Entrez Gene: 268930 Mouse
Entrez Gene: 287101 Rat
Omim: 602474 Human
SwissProt: Q99640 Human
SwissProt: Q9ESG9 Mouse
Unigene: 77783 Human
Unigene: 182193 Mouse
Unigene: 204349 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
由该基因编码的蛋白质是含有神经特异性锌指的DNA结合蛋白家族的成员。该蛋白与中枢神经系统的蛋白脂质蛋白的启动子区结合，并在发育中的神经系统中发挥作用。[ RefSeq，JUL 2008 ]