FITC标记的磷酸化心脏肌球蛋白轻链2抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化心脏肌球蛋白轻链2抗体
英文名称: Anti-Phospho-MYL(Ser19)/FITC
抗体货号: HZ-3295R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 10:39:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-MYL(Ser19)/FITC Conjugated antibody

FITC标记的***酸化心脏肌球蛋白轻链2抗体

 

英文名称 Anti-Phospho-MYL(Ser19)/FITC
中文名称 FITC标记的***酸化心脏肌球蛋白轻链2抗体
别    名 Cardiac myosin light chain-2; Cardiac ventricular myosin light chain 2; CMH10; MLC 2v; MLC2; MYL 2; Myosin light chain 2 regulatory cardiac slow; Myosin light polypeptide 2 regulatory cardiac slow; Myosin regulatory light chain 2 ventricular cardiac muscle isoform; Myosin regulatory light chain 2; ventricular/cardiac muscle isoform; Regulatory light chain of myosin; RLC of myosin; Slow cardiac myosin regulatory light chain 2; MLRV_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 心血管  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MYL2 around the phosphorylation site of Ser19
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Subunit:
Myosin is a hexamer of 2 heavy chains and 4 light chains.

Subcellular Location:
Cytoplasm, myofibril, sarcomere, A band 

Post-translational modifications:
N-terminus is methylated by METTL11A/NTM1. 
Phosphorylated by MYLK3. 

DISEASE:
Defects in MYL2 are the cause of familial hypertrophic cardiomyopathy type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Similarity:
Contains 3 EF-hand domains.

Database links:

Entrez Gene: 4633 Human

Entrez Gene: 17906 Mouse

Entrez Gene: 363925 Rat

Omim: 160781 Human

SwissProt: P10916 Human

SwissProt: P51667 Mouse

SwissProt: P08733 Rat

Unigene: 75535 Human

Unigene: 1529 Mouse

Unigene: 37176 Rat

Unigene: 6534 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   
 
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   

因此,基因编码与心肌肌球蛋白β(或慢)重链相关的调节轻链。Ca+触发调节性轻链的***酸化,进而触发收缩。该基因的突变与左心室中室型肥厚型心肌病相关。[ RefSeq,JUL 2008 ]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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