FITC标记的磷酸化星形胶质细胞PEA15抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化星形胶质细胞PEA15抗体
英文名称: Anti-Phospho-PEA15(Ser116)/FITC
抗体货号: HZ-3329R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/10 13:39:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-PEA15(Ser116)/FITC Conjugated antibody

FITC标记的***酸化星形胶质细胞PEA15抗体

 

英文名称 Anti-Phospho-PEA15(Ser116)/FITC
中文名称 FITC标记的***酸化星形胶质细胞PEA15抗体
别    名 PEA15(Phospho Ser116); PEA15 (Phospho-S116); p-PEA15 (116); Astrocytic phosphoprotein PEA 15; Astrocytic phosphoprotein PEA15; HMAT 1; HMAT1; Homolog of mouse MAT 1 oncogene; Homolog of mouse MAT1 oncogene; HUMMAT 1H; HUMMAT1H; MAT 1; MAT 1H; MAT1; MAT1H; PEA 15; PEA-15; PEA15 protein; PED; Phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes 15kD; Phosphoprotein enriched in diabetes.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 免疫学  神经生物学  信号转导  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PEA15 around the phosphorylation site of Ser116
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PED/PEA 15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15 kDa) is a widely expressed 15 kDa protein comprised of an N terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C terminal region containing two serine phosphorylation sites. PED/PEA 15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin sensitive glucose transport in insulin responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA 15 function.

Function:
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Subunit:
Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.

Similarity:
Contains 1 DED (death effector) domain.

Database links:

Entrez Gene: 8682 Human

Entrez Gene: 18611 Mouse

Omim: 603434 Human

SwissProt: Q15121 Human

SwissProt: Q62048 Mouse

Unigene: 517216 Human

Unigene: 544 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

PED /豌豆15(富含糖尿病/***酸化蛋白富集的星形胶质细胞15kDa***蛋白)是一种广泛表达的15 kDa蛋白包括一个N端含有一个典型的死亡效应结构域(DED)序列和核输出信号,和一个C端区域包含两个丝氨酸***酸化位点。PED /豌豆15有牵连的多种细胞过程,包括细胞凋亡、调节整合素的活化,并在胰岛素敏感细胞胰岛素敏感的葡萄糖转运。的***酸化丝氨酸104(蛋白激酶C网站)和丝氨酸116(CaMKII和Akt底物)是PED /豌豆15功能要求。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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