FITC标记的G蛋白偶联受体109A抗体上海沪震实业有限公司

金牌供应商

性能参数

产品名称: FITC标记的G蛋白偶联受体109A抗体
英文名称: Anti-GPR109A/FITC
抗体货号: HZ-10079R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/9/13 10:55:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:932点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
在线QQ: 我是2043711056,请问我有什么可以帮到您呢?
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
邮件:
公司展台:
在线QQ:
我是2043711056,请问我有什么可以帮到您呢?
扫一扫,关注我们

产品详细描述

 Rabbit Anti-GPR109A/FITC Conjugated antibody 

FITC标记的G蛋白偶联受体109A抗体

 

英文名称Anti-GPR109A/FITC中文名称FITC标记的G蛋白偶联受体109A抗体别    名HM74A; G-protein coupled receptor 109A; GPR109A; HM74a; HM74b; NIACR1; Puma-g; PUMAG; Niacr1; Niacin receptor 1; Nicotinic acid receptor; G-protein coupled receptor 109; G-protein coupled receptor HM74; G protein coupled receptor HM74a; G protein coupled receptor Hm74b; Protein PUMA-G; Interferon gamma inducible gene Puma g; Nicotinic acid receptor 1; Nicotinic acid receptor; Puma g; Pumag; rHM74b; HCAR2_HUMAN .  规格价格100ul/2980元 购买        大包装/询价说 明 书100ul  研究领域抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Cow, Rabbit, 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量40kDa细胞定位细胞膜 性    状Lyophilized or Liquid浓    度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human GPR109A/HM74A亚    型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.

Function:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 338442 Human

Omim: 609163 Human

SwissProt: Q8TDS4 Human

Unigene: 524812 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   

作为烟酸(又称烟酸)和(D)-β-羟基丁酸的高亲和力受体,并通过G(I)介导增加脂联素分泌和减少脂解作用-蛋白介导的腺苷酸环化酶抑制。这种药理作用需要烟酸剂量远远高于正常饮食所提供的烟酸剂量。介导烟酸诱导成熟中性粒细胞凋亡。烟酸的受体激活导致cAMP水平降低,这可能影响cAMP依赖性蛋白激酶A的活性和靶蛋白的***酸化,从而导致中性粒细胞凋亡。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看FITC标记的G蛋白偶联受体109A抗体产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要