FITC标记的补体C1S链多肽抗体上海沪震实业有限公司

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产品名称: FITC标记的补体C1S链多肽抗体
英文名称: Anti-C1s /FITC
抗体货号: HZ-15088R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 11:26:00
详细资料:  实验方法技术资料
浏览人数:5
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-C1s /FITC Conjugated antibody

FITC标记的补体C1S链多肽抗体

 

英文名称 Anti-C1s /FITC
中文名称 FITC标记的补体C1S链多肽抗体
别    名 Basic proline rich peptide IB 1; C1 esterase; C1S; C1S_HUMAN; Complement C1s subcomponent; Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain; Complement component 1 s subcomponent; Complement component 1 subcomponent s; FLJ44757.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47/75kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1s
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathway of the serum complement system. C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q in a 2:2:1 ratio. Activated C1s is in the form of a disulfide-linked heterodimer consisting of a heavy chain and a light chain. Defects in the gene encoding for C1s can cause selective C1s deficiency, a disorder characterized by early onset of various autoimmune diseases.

Function:
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. 

Subunit:
C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.

Post-translational modifications:
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

DISEASE:
Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. 

Similarity:
Belongs to the peptidase S1 family. 
Contains 2 CUB domains. 
Contains 1 EGF-like domain. 
Contains 1 peptidase S1 domain. 
Contains 2 Sushi (CCP/SCR) domains. 

Database links:

Entrez Gene: 716 Human

Entrez Gene: 50908 Mouse

Entrez Gene: 192262 Rat

Omim: 120580 Human

SwissProt: P09871 Human

SwissProt: Q8CG14 Mouse

SwissProt: Q6P6T1 Rat

Unigene: 458355 Human

Unigene: 4037 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

补体组分蛋白C1、C3、C4和C5是补体激活过程中释放的有效过敏毒素。这些蛋白与它们各自的G蛋白偶联受体的结合诱导促炎事件,如细胞脱颗粒、平滑肌收缩、花生四烯酸代谢、细胞因子释放、白细胞活化和细胞趋化。C1q与酶原C1R和C1S一起产生C1,这是血清补体系统经典途径的第一个组成部分。C1由钙依赖的三分子配合物C1R、C1S和C1q组成,比例为2∶2∶1。活性C1S是由重链和轻链组成的二硫键异二聚体的形式。编码C1s的基因的缺陷可导致选择性C1s缺乏,一种以各种自身免疫性疾病的早期发病为特征的疾病。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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