FITC标记的DNA甲基转移酶相关蛋白1抗体上海沪震实业有限公司

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产品名称: FITC标记的DNA甲基转移酶相关蛋白1抗体
英文名称: Anti-DMAP1/FITC
抗体货号: HZ-13009R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 11:53:00
详细资料:  实验方法技术资料
浏览人数:10
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-DMAP1/FITC Conjugated antibody

FITC标记的DNA甲基转移酶相关蛋白1抗体

 

英文名称 Anti-DMAP1/FITC
中文名称 FITC标记的DNA甲基转移酶相关蛋白1抗体
别    名 DKFZp686L09142; DMAP 1; DNA methyltransferase 1-associated protein 1; DNMAP 1; DNMAP1; DNMT1-associated protein 1; DNMT1-associated protein 1; DNMTAP 1; DNMTAP1; EAF 2; EAF2; FLJ11543; KIAA1425; MAT 1-mediated transcriptional repressor; MGC55593; SWC 4; SWC4; zgc:55593.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, Xenopus laevis
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DMAP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Methylation of DNA contributes to the regulation of gene transcription in eukaryotic systems. DNA methylation is predominantly found on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by a guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferases (DNMTs), which results in transcriptional repression of the methylated gene. DNA methyltransferase 1-associating protein (Dmap1) binds to methyl-CpG rich domains and mediate the transcriptional inhibition associated with DNA methylation. Dmap1 interacts with Daxx to enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. Daxx also protects Dmap1 from protein degradation in vivo.

Function:
DMAP1 is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. 

Subunit:
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSin3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with the pro-apoptotic protein DAXX. Interacts with URI1.

Subcellular Location:
Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.

Similarity:
Contains 1 SANT domain. 

Database links:

Entrez Gene: 55929 Human

Entrez Gene: 66233 Mouse

Entrez Gene: 298447 Rat

Omim: 605077 Human

SwissProt: Q9NPF5 Human

SwissProt: A2ADW4 Mouse

SwissProt: Q9JI44 Mouse

SwissProt: Q568Y6 Rat

Unigene: 8008 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

DNA甲基化有助于真核系统中基因转录的调控。DNA甲基化主要存在于由5’胞嘧***和鸟苷(CpG)组成的二核苷酸基序中的胞嘧***残基上,它需要DNA甲基转移酶(DNMTs)的酶活性,从而导致甲基化基因的转录抑制。DNA甲基转移酶1相关蛋白(Dmap1)与富含甲基CpG的区域结合,并介导与DNA甲基化相关的转录抑制。DMAP1与Daxx相互作用以增强DAXX介导的糖皮质***受体转录活性的抑制。DAXX还保护了DMAP1在体内的蛋白质降解。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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