FITC标记的胶质细胞谷氨酸运载蛋白4抗体上海沪震实业有限公司

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产品名称: FITC标记的胶质细胞谷氨酸运载蛋白4抗体
英文名称: Anti-EAAT4/FITC
抗体货号: HZ-13046R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 8:55:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-EAAT4/FITC Conjugated antibody

FITC标记的胶质细胞谷氨酸运载蛋白4抗体

 

英文名称 Anti-EAAT4/FITC
中文名称 FITC标记的胶质细胞谷氨酸运载蛋白4抗体
别    名 Excitatory amino acid transporter 4; SLC1A6; High affinity neuronal glutamate transporter; MGC33092; MGC43671; Sodium dependent glutamate/aspartate transporter; Solute carrier family 1 (high affinity aspartate/glutamate transporter) member 6; Solute carrier family 1 member 6;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  染色质和核信号  转录调节因子  转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EAAT4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.

Function:
EAAT4 is expressed predominantly in the cerebellum (Purkinje cells) and weakly in the forebrain, where it transports L-glutamate, L-aspartate and D-aspartate, acting as a symport by cotransporting sodium. EAAT4 may function as a combined transporter and inhibitory glutamate receptor and also functions as an anion-selective ion channel. 

Subcellular Location:
Membrane; multi-pass membrane protein. 

Tissue Specificity:
Brain. Expressed densely and selectively incell bodies of Purkinje cells.

Similarity:
Belongs to the sodium:dicarboxylate (SDF) symporter(TC 2.A.23) family. SLC1A6 subfamily. 

Database links:

Entrez Gene: 6511 Human

Entrez Gene: 20513 Mouse

Entrez Gene: 84012 Rat

Omim: 600637 Human

SwissProt: P48664 Human

SwissProt: O35544 Mouse

SwissProt: O35921 Rat

Unigene: 10827 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

兴奋性氨基酸转运体(EAAT)是膜结合蛋白,定位于神经胶质细胞和突触前谷氨酸神经末梢。EAAT转运兴奋性神经递质L-谷氨酸和D-天冬氨酸,这一过程对于终止谷氨酸的突触后作用至关重要。EAAT蛋白对氨基酸类神经递质的再摄取已被证明能够保护神经元免受由氨基酸类神经递质积累引起的兴奋毒性。EAAT4是一种天冬氨酸/谷氨酸转运体,主要在小脑中表达。EAAT4编码的转运活性对L-天冬氨酸和L-谷氨酸具有高的表观亲和力,并且具有与先前描述的小脑转运活性一致的药理学特征。EAAT5是一种谷氨酸转运体,与氯离子电导偶联,主要在视网膜中表达。虽然EAAT5与EAAT家族的结构同源性相同,但EAAT5序列的一个新特征是先前在N-乙基-D-天冬氨酸受体和钾通道中鉴定的羧基端基序,并显示出与促进ch的突触蛋白家族具有相互作用。ANNEL聚类

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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