FITC标记的脑啡肽A抗体上海沪震实业有限公司

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产品名称: FITC标记的脑啡肽A抗体
英文名称: Anti-Dynorphin A/FITC
抗体货号: HZ-13041R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:02:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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电话:
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传真:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-Dynorphin A/FITC Conjugated antibody

FITC标记的脑啡肽A抗体

 

英文名称 Anti-Dynorphin A/FITC
中文名称 FITC标记的脑啡肽A抗体
别    名 Beta neoendorphin dynorphin; Dyn A17; Dynorphin A; PDYN; Preprodynorphin; Proenkephalin B; PDYN_HUMAN; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8) .  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Monkey, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 2/28kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dynamin 3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20∑C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ∑C.
产品介绍 background:
The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The Proenkephalin proteins are proteolytically processed to form active secreted opioid peptides, which function as ligands for the ⅹ-type of opioid receptor. The Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides, while the Proenkephalin B precursor contains beta-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and rimorphin processed active peptides. beta-endorphin and Met-enkephalin are endogenous opiates, while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases melanin production in melanocytes, which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP kinase and PI 3-kinase pathways.

Function:
Dynorphins are a class of peptides produced by many different populations of neurons, which has some opiate like activity. It is thus classed as an endogenous opioid peptide. The dynorphins, which include dynorphin A, dynorphin B, alpha and beta neoendorphin, and big dynorphin, are all the products of a single gene, 'preprodynorphin'. Dynorphin is produced in many different parts of the brain, including the hypothalamus, the hippocampus and the spinal cord, and has many different physiological actions, depending upon its site of production. Dynorphin is involved in modulating responses to several psychoactive substances, including ***. As such, it may help some individuals against addiction. Blocking dynorphin may help alleviate depression.

Subcellular Location:
Secreted

Post-translational modifications:
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

DISEASE:
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. 

Similarity:
Belongs to the opioid neuropeptide precursor family. 

Database links:

Entrez Gene: 5173 Human

Entrez Gene: 18610 Mouse

Entrez Gene: 29190 Rat

Omim: 131340 Human

SwissProt: Q95104 Cow

SwissProt: P01213 Human

SwissProt: O35417 Mouse

SwissProt: P06300 Rat

Unigene: 22584 Human

Unigene: 44471 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

前脑啡肽前体蛋白属于阿片神经肽前体家族的分泌蛋白。前脑啡肽蛋白被蛋白水解形成活性分泌的阿片肽,其作为型阿片受体的配体。前脑啡肽A前体含有脑啡肽、亮脑啡肽和甲硫脑啡肽加工的活性肽,而前脑啡肽B前体含有β-新内啡肽、强啡肽、亮啡肽、亮脑啡肽和利莫啡加工的活性肽。β-内啡肽和甲硫脑啡肽是内源性阿片类药物,而ACTH是肾上腺刺激释放皮质醇的关键。MSH增加黑素细胞的黑色素生成,从而导致皮肤色素沉着增加。Leop啡肽通过参与MAP激酶和PI-3激酶途径在细胞凋亡预防中可能是重要的。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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