FITC标记的紧密连接蛋白2抗体上海沪震实业有限公司

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产品名称: FITC标记的紧密连接蛋白2抗体
英文名称: Anti-TJP2/FITC
抗体货号: HZ-4844R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:06:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
传真:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-TJP2/FITC Conjugated antibody 

FITC标记的紧密连接蛋白2抗体

 

英文名称 Anti-TJP2/FITC
中文名称 FITC标记的紧密连接蛋白2抗体
别    名 Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; Tight junction protein 2; Tight junction protein ZO 2; Tight junction protein ZO-2; TJP2; X104; ZO 2; ZO-2; ZO2; ZO2_HUMAN; Zona occludens protein 2; Zonula occludens protein 2  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, Guinea Pig, Danio rerio
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 131kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TJP2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Function:
Plays a role in tight junctions and adherens junctions

Subunit:
Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB.

Subcellular Location:
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.

Tissue Specificity:
This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.

DISEASE:
Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.

Similarity:
Belongs to the MAGUK family. 
Contains 1 guanylate kinase-like domain. 
Contains 3 PDZ (DHR) domains. 
Contains 1 SH3 domain.

Database links:

Entrez Gene: 9414 Human

Entrez Gene: 21873 Mouse

Entrez Gene: 115769 Rat

Omim: 607709 Human

SwissProt: Q9UDY2 Human

SwissProt: Q9Z0U1 Mouse

Unigene: 50382 Human

Unigene: 104744 Mouse

Unigene: 10965 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码一个膜小带,它是膜相关鸟苷酸激酶同系物家族的成员。编码蛋白是上皮细胞和内皮细胞紧密连接屏障的组成部分,是紧密连接正确组装所必需的。该基因的突变已经在高胆碱血症患者中鉴定出来,包括该基因在内的270kb区域的基因组重复导致常染色体显性聋-51。另一种编码多个异构体的剪接转录本已被观察到该基因。[ RefSeq,NOV 2011 ]提供。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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