FITC标记的恶性肿瘤丢失蛋白EPLIN抗体上海沪震实业有限公司

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产品名称: FITC标记的恶性肿瘤丢失蛋白EPLIN抗体
英文名称: Anti-EPLIN/FITC
抗体货号: HZ-13086R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:48:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-EPLIN/FITC Conjugated antibody

FITC标记的恶性肿瘤丢失蛋白EPLIN抗体

 

英文名称 Anti-EPLIN/FITC
中文名称 FITC标记的恶性肿瘤丢失蛋白EPLIN抗体
别    名 1110021C24Rik; Epithelial protein lost in neoplasm; Epithelial protein lost in neoplasm beta; EPLIN; FLJ38853; LIM domain and actin binding 1; LIM domain and actin binding protein 1; LIM domain and actin-binding protein 1; LIMA1; LIMA1_HUMAN; MGC131726; SREBP3; Sterol regulatory element binding protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EPLIN
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Epithelial protein lost in neoplasm (EPLIN) is a cytoskeleton-associated protein characterized by the presence of a single centrally located lin-11, isl-1 and mec-3 (LIM) domain. It also contains at least two Actin-binding domains, in which the C-terminal domain binds more effectively than the N-terminal domain. By binding Actin monomers and filaments, EPLIN is involved in regulation of the Actin cytoskeleton by increasing the number and size of Actin stress fibers, delaying filament nucleation, reducing formation of branched filaments and bundling of Actin filaments. It also inhibits membrane ruffling and Actin filament depolymerization. EPLIN is strongly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart, and to a lesser degree in lung, liver, brain, skeletal muscle, thymus, testis and intestine. It is expressed as two isoforms, EPLIN-α and EPLIN-β. Downregulation of EPLIN-α expression may contribute to the motility of invasive tumor cells.

Function:
Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.

Subcellular Location:
Cytoplasm. Cell junction > focal adhesion. Cytoplasm > cytoskeleton. This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.

Tissue Specificity:
Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.

Similarity:
Contains 1 LIM zinc-binding domain.

Database links:

Entrez Gene: 51474 Human

Entrez Gene: 65970 Mouse

Omim: 608364 Human

SwissProt: Q9UHB6 Human

SwissProt: Q9ERG0 Mouse

Unigene: 525419 Human

Unigene: 33207 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

肿瘤中上皮蛋白丢失(EPLIN)是一种细胞骨架相关蛋白,其特点是存在单个中心定位的lin-11、isl-1和mec-3(LIM)结构域。它还包含至少两个Actin结合域,其中C端域比N端域更有效地结合。通过结合肌动蛋白单体和丝,EPLIN通过增加肌动蛋白应力纤维的数量和大小,延缓丝成核,减少分支丝的形成和肌动蛋白丝的束缚,参与调节肌动蛋白细胞骨架。它还抑制膜皱褶和肌动蛋白丝解聚。EPLIN在胎盘、肾脏、胰腺、前列腺、卵巢、脾脏和心脏中均有强表达,在肺、肝、脑、骨骼肌、胸腺、睾丸和肠中表达较弱。它表达为两种异构体,即EPLINα和EPLINβ。EpLINα表达下调可能有助于侵袭性肿瘤细胞的运动。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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