FITC标记的磷酸化HER3抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化HER3抗体
英文名称: Anti-Phospho-HER3 (Tyr1276)/FITC
抗体货号: HZ-13092R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:14:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Phospho-HER3 (Tyr1276)/FITC Conjugated antibody

FITC标记的***酸化HER3抗体

 

英文名称 Anti-Phospho-HER3 (Tyr1276)/FITC
中文名称 FITC标记的***酸化HER3抗体
别    名 Her3/ErbB3(phospho-Tyr1276); p-HRE3 (Tyr1276); ErbB 3 (phospho Y1276); ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c ErbB 3; proto-oncogene-like protein c ErbB3; receptor tyrosine protein kinase ERB3; Receptor tyrosine protein kinase erbB 3; Receptor tyrosine protein kinase erbB3; Tyrosine kinase type cell surface receptor HER3; ERBB3_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  细胞膜受体  G蛋白偶联受体  肿瘤细胞生物标志物  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat, Dog, Pig, Cow, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 148kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1276
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2); also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.

Function:
Binds and is activated by neuregulins and NTAK.

Subunit:
Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7 and MUC1.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I. membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Epithelial tissues and brain.

Post-translational modifications:
Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. Subject to autophosphorylation.

DISEASE:
Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.

Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family. 
EGF receptor subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 2065 Human

Entrez Gene: 13867 Mouse

Entrez Gene: 29496 Rat

Omim: 190151 Human

SwissProt: P21860 Human

SwissProt: Q61526 Mouse

SwissProt: Q62799 Rat

Unigene: 118681 Human

Unigene: 373043 Mouse

Unigene: 10228 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

 

ERBB3是受体酪氨酸激酶的表皮生长因子受体(EGFR)家族的成员。ERBB3是一个膜结合蛋白,具有神经调节蛋白结合结构域,而不是活性激酶结构域。因此,它可以结合该配体,但不能通过蛋白质***酸化将信号传递到细胞中。然而,它确实与其他具有EGF受体家族成员的异源二聚体具有激酶活性。异源二聚导致通路的激活,导致细胞增殖或分化。该基因的扩增和/或其蛋白的过表达已被报道在许多癌症中,包括前列腺癌、膀胱癌和乳腺癌。已经鉴定了编码不同亚型的交替转录剪接变异体。异构体2缺乏膜间区,并在细胞外分泌。这种形式的作用是调节膜结合形式的活性。还报道了附加剪接变异体,但它们尚未被完全表征。ERBB3的缺陷是致死性先天性挛缩综合征2型(LCCS2)的原因,也称为以色列贝都因多发性挛缩综合征A型。E脊髓。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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