FITC标记的T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体
产品名称： FITC标记的T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体
英文名称： Anti-ETEA/FITC
产品编号： HZ-13109R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ETEA/FITC Conjugated antibody
FITC标记的T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体
| 英文名称 | Anti-ETEA/FITC |
| 中文名称 | FITC标记的T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体 |
| 别 名 | AI462440; expressed in T cells and eosinophils in atopic dermatitis; faf2; FAF2_HUMAN; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; Protein expressed in T cells and eosinophils in atopic dermatitis; Protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞凋亡 淋巴细胞 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ETEA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ETEA is a 445-amino acid protein associated with atopic dermatitis (AD), a chronic noncontagious relapsing inflammatory skin disease characterized by eczematous skin lesions and also referred to as eczematous dermatitis. Other atopic diseases such as hay fever, asthma and conjunctivitis often occur along with AD. ETEA shows higher expression in T cells and eosinophils of patients with AD than in T cells and eosinophils of unaffected individuals. T cells are influential in the regulation of the inflammatory process of this disease. The persistence of jAD is attributed to dysregulated apoptosis in T cells, eosinophils, and keratinocytes. ETEA may be involved in the resistance to apoptosis in T cells and eosinophils of AD patients. Function: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Subunit: Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Subcellular Location: Cytoplasm. Lipid droplet. Endoplasmic reticulum. Tissue Specificity: Broadly expressed, with highest levels in brain. Similarity: Contains 1 UBX domain. Database links: UniProtKB/Swiss-Prot: Q96CS3.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ETEA是一种445氨基酸的蛋白质，与特应性皮炎（AD）相关，AD是一种以湿疹性皮肤损害为特征的慢性非传染性复发性炎症性皮肤病，也称为湿疹性皮炎。其他特应性疾病如花粉热、哮*和结膜炎常伴随AD发生。ETEA在AD患者的T细胞和嗜酸性粒细胞中的表达高于未受影响的个体的T细胞和嗜酸性粒细胞。T细胞在调节该疾病的炎症过程中具有重要作用。JAD的持续性归因于T细胞、嗜酸性粒细胞和角质形成细胞的凋亡失调。ETA可能参与AD患者T细胞和嗜酸性粒细胞凋亡的抵抗。