FITC标记的FHOD3蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的FHOD3蛋白抗体
英文名称: Anti-FHOD3/FITC
抗体货号: HZ-13156R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 11:12:00
详细资料:  实验方法技术资料
浏览人数:23
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-FHOD3/FITC Conjugated antibody 

FITC标记的FHOD3蛋白抗体

 

英文名称 Anti-FHOD3/FITC
中文名称 FITC标记的FHOD3蛋白抗体
别    名 FLJ22717; Formactin2; FH1/FH2 domain containing protein 3; FH1/FH2 domain-containing protein 3; Fhod3; FHOD3_HUMAN; FHOS2; FLJ22297; FLJ22717; Formactin-2; Formactin2; Formin homolog overexpressed in spleen 2; Formin homology 2 domain containing 3; hFHOS2; KIAA1695; mKIAA1695.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  细胞骨架  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 159kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Supervillin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
FHOD3 (formin homology 2 domain containing 3), also known as FHOS2 or KIAA1695, is a 1,422 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one DAD domain, one FH1 domain, one FH2 domain and one GBD/FH3 domain. Expressed in brain, heart and kidney, FHOD3 interacts with intermediate filaments and functions as an Actin-organizing protein that is thought to promote the formation of stress fibers in conjunction with cellular elongation. Multiple isoforms of FHOD3 exist due to alternative splicing events. The gene encoding FHOD3 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.

Function:
Actin-organizing protein that may cause stress fiber formation together with cell elongation.

Subunit:
Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding.

Subcellular Location:
Cytoplasm; cytoskeleton. Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining.

Tissue Specificity:
Expressed in the heart, kidney and brain.

Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

Database links:
Entrez Gene: 80206 Human
Entrez Gene: 225288 Mouse
Entrez Gene: 291731 Rat
Omim: 609691 Human
SwissProt: Q2V2M9 Human
SwissProt: Q76LL6 Mouse
Unigene: 630884 Human
Unigene: 329322 Mouse


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

FHOD3(甲酸同系物2结构域包含3),也称为FHOS2或KIAA1695,是一种1422个氨基酸蛋白,定位于细胞质和细胞骨架,并包含一个DAD结构域、一个FH1结构域、一个FH2结构域和一个GbD/FH3结构域。在大脑、心脏和肾脏中表达,FHOD3与中间丝相互作用,并起到肌动蛋白组织蛋白的作用,被认为促进结合细胞伸长的应力纤维的形成。FHD3的多个异构体由于选择性剪接事件而存在。编码FHOD3的基因定位于人类18号染色体,其含有超过300个蛋白质编码基因并含有近7600万个碱基。在染色体18定位基因中存在多种疾病,其中一些包括三体性18(也称为爱德华兹综合征)、尼曼-匹克病、遗传性出血性毛细血管扩张症、红细胞生成性原卟啉症和滤泡性淋巴瘤。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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