FITC标记的Fcγ免疫球蛋白IgG结合蛋白抗体
产品名称： FITC标记的Fcγ免疫球蛋白IgG结合蛋白抗体
英文名称： Anti-FCGBP/FITC
产品编号： HZ-13168R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FCGBP/FITC Conjugated antibody
FITC标记的Fcγ免疫球蛋白IgG结合蛋白抗体
| 英文名称 | Anti-FCGBP/FITC |
| 中文名称 | FITC标记的Fcγ免疫球蛋白IgG结合蛋白抗体 |
| 别 名 | Fc fragment of IgG binding protein; FC(GAMMA)BP; Fcgamma-binding protein antigen; FcgammaBP; FCGBP; FCGBP_HUMAN; Human Fc gamma BP; IgGFc-binding protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 569kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCGBP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains. It is predominantly expressed in placenta and colon epithelium as well as in thyroid and serum. Patients with various autoimmune diseases seemingly have higher levels of FCGBP protein present in their serum. Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Subunit: Interacts with the Fc portion of IgG and with MUC2. Subcellular Location: Secreted. Tissue Specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level). Similarity: Contains 12 TIL (trypsin inhibitory-like) domains. Contains 13 VWFD domains. Database links: Entrez Gene: 8857 Human SwissProt: Q9Y6R7 Human Unigene: 111732 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Fc（Ig恒定片段）受体通过从循环中除去Ig包被的抗原复合物，确保宿主免受外来抗原，如微生物和病原体的保护。Fc受体存在于淋巴和髓系衍生物上，它们介导Ig-抗原复合物的内吞作用、通过T细胞抗原呈递在B细胞中产生抗体、细胞毒性和细胞因子及活性氧的释放。Fcγ结合蛋白（FCGBP）与IgG和MUC2的Fc部分相互作用，介导粘膜结构的维持。FCGBP是一个含有5405个TIL（胰蛋白酶抑制样）结构域和十三个VWFD结构域的十二个氨基酸的蛋白质。它主要在胎盘和结肠上皮以及甲状腺和血清中表达。各种自身免疫性疾病的患者似乎有较高水平的FCGBP蛋白存在于他们的血清中。