Rabbit Anti-DHODH/FITC Conjugated antibody
|别 名||DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondrial; PYRD_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 信号转导 细胞骨架|
|交叉反应||Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||43kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DHODH|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Mitochondrion inner membrane.
The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.
Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Entrez Gene: 1723 Human
Entrez Gene: 533873 Cow
Entrez Gene: 610755 Dog
Entrez Gene: 56749 Mouse
Entrez Gene: 65156 Rat
Entrez Gene: 494065 Zebrafish
Omim: 126064 Human
SwissProt: Q02127 Human
SwissProt: O35435 Mouse
SwissProt: Q63707 Rat
Unigene: 654427 Human
Unigene: 23894 Mouse
Unigene: 81502 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因编码的蛋白催化了新嘧***生物合成中的第四个酶学步骤，泛醌介导的二氢氟酸盐氧化为氟酸盐。这种蛋白质是位于线粒体内膜的外表面的线粒体蛋白。[ RefSeq，JUL 2008 ]