Rabbit Anti-DIXDC1/FITC Conjugated antibody
|别 名||CCD1; Ccd1Aalpha1L; Ccd1Abeta1L; Ccd1BalphaL; Ccd1BbetaL; Ccd1CL; Coiled coil DIX1; Coiled coil protein DIX1; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain containing 1; DIX domain containing protein 1; DIX domain-containing protein 1; DIXC1_HUMAN; DIXDC1; Dixin; KIAA1735.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||心血管 细胞生物 信号转导 干细胞 激酶和***酸酶 细胞骨架|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||77kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DIXDC1|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Cytoplasm; Cell junction; focal adhesion. Associated with actin stress fiber at the filament ends and Cytoplasm; cytosol. Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis.
Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
Phosphorylated on tyrosine and serine residues. Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
Belongs to the DIXDC1 family.
Contains 1 CH (calponin-homology) domain.
Contains 1 DIX domain.
Entrez Gene: 85458 Human
Omim: 610493 Human
SwissProt: Q155Q3 Human
Unigene: 655626 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因编码的蛋白是Wnt信号通路的正调控因子。编码的蛋白与中心体γ-微管蛋白相关。选择性剪接导致多个转录子变体编码不同的亚型。[ RefSeq 2013军提供]