FITC标记的DNAJC14蛋白抗体
产品名称： FITC标记的DNAJC14蛋白抗体
英文名称： Anti-DNAJC14/FITC
产品编号： HZ-14381R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-DNAJC14/FITC Conjugated antibody
FITC标记的DNAJC14蛋白抗体
| 英文名称 | Anti-DNAJC14/FITC |
| 中文名称 | FITC标记的DNAJC14蛋白抗体 |
| 别 名 | DJC14_HUMAN; DnaJ (Hsp40) homolog, subfamily C, member 14; DNAJ; DnaJ homolog subfamily C member 14; DnaJ protein homolog 3; DNAJC14; Dopamine receptor interacting protein; Dopamine receptor-interacting protein of 78 kDa; DRiP78; hDj 3; HDJ-3; HDJ3; Human DnaJ protein 3; LIP6; LYST interacting protein LIP6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DNAJC14 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJC14 (DnaJ homolog subfamily C member 14), also known as DRIP78 (Dopamine receptor-interacting protein of 78 kDa) and HDJ3 (Human DnaJ protein 3), is a 702 amino acid endoplasmic reticulular membrane protein that contains one J domain. DnaJC14 regulates the export of target proteins, such as the dopamine D1 receptor (D1DR), from the endoplasmic reticulum to the cell surface. Function: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney. Similarity: Contains 1 J domain. Database links: Entrez Gene: 85406 Human Entrez Gene: 74330 Mouse Entrez Gene: 114481 Rat Omim: 606092 Human SwissProt: Q6Y2X3 Human SwissProt: Q921R4 Mouse SwissProt: Q5XIX0 Rat Unigene: 709320 Human Unigene: 296915 Mouse Unigene: 114340 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DnaJ家族是所有伴侣家族中最大的家族之一，并且已经演化为具有多种细胞定位和功能的家族。J域的存在定义了作为DnaJ家族成员的蛋白质。DnaJ热休克诱导蛋白来源于大肠杆菌，受htpR调节蛋白的控制。DHNJ蛋白通过与HSP 70相互作用，在HSP 70伴侣机器中起关键作用，以刺激ATP水解。DnaJ蛋白是蛋白水解的重要介质，参与蛋白质降解、胞吐和胞内吞的调节。DnaJC14(DnaJ同源亚家族C成员14)，又称DRIP78(78kDa的多巴胺受体相互作用蛋白)和HDJ3(人DnaJ蛋白3)，是一种含有一个J结构域的702氨基酸内质网状膜蛋白。DnaJC14调节靶蛋白如多巴胺D1受体（D1DR）从内质网向细胞表面的出口。