FITC标记的组蛋白赖氨酸N-甲基SETMAR抗体
产品名称： FITC标记的组蛋白赖氨酸N-甲基SETMAR抗体
英文名称： Anti-SETMAR/FITC
产品编号： HZ-19672R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SETMAR/FITC Conjugated antibody
FITC标记的组蛋白赖氨酸N-甲基SETMAR抗体
| 英文名称 | Anti-SETMAR/FITC |
| 中文名称 | FITC标记的组蛋白赖氨酸N-甲基SETMAR抗体 |
| 别 名 | Histone lysine N methyltransferase; Histone lysine N methyltransferase SETMAR; Hsmar 1; Hsmar1; Mariner transposase Hsmar1; Metnase; SET domain and mariner transposase fusion; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene containing protein; SET domain and mariner transposase fusion gene-containing protein; Setmar; SETMR_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 77kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SETMAR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] Function: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. Subcellular Location: Nucleus. Chromosome. Tissue Specificity: Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. Similarity: In the N-terminal section; belongs to the histone-lysine methyltransferase family. In the C-terminal section; belongs to the mariner transposase family. Contains 1 post-SET domain. Contains 1 pre-SET domain. Contains 1 SET domain. Database links: Entrez Gene: 6419 Human Omim: 609834 Human SwissProt: Q53H47 Human Unigene: 475300 Human Unigene: 716054 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码包含N-末端组蛋白-赖氨酸N-甲基转移酶域和C-末端水手转座酶域的融合蛋白。该编码蛋白结合DNA并在DNA修复活动中起作用，包括非同源末端连接和双链断裂修复。该蛋白的设置域部分特异性地甲基化组蛋白H3赖氨酸4和36。该基因仅在类人猿灵长类动物中作为融合基因存在，其他生物缺乏水杨酸转座酶结构域。交替剪接导致多个转录变体。[ RefSeq，2013月1日]