FITC标记的ETS结构域转录因子FEV抗体上海沪震实业有限公司

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产品名称: FITC标记的ETS结构域转录因子FEV抗体
英文名称: Anti-Pet1/FITC
抗体货号: HZ-20434R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 15:09:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Pet1/FITC Conjugated antibody 

FITC标记的ETS结构域转录因子FEV抗体

 

英文名称 Anti-Pet1/FITC
中文名称 FITC标记的ETS结构域转录因子FEV抗体
别    名 ETS-domain transcription factor; FEV; FEV_HUMAN; Fifth Ewing variant protein; mPet1; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1; Protein FEV.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  转录调节因子  Alzheimer's  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应  
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pet1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes currently includes Ets-1, Ets-2, Erg-1–3, Elk-1, Elf-1, Elf-5, NERF, PU.1, PEA3, ERM, FEV, ER8l, Fli-1, TEL, Spi-B, ESE-1, ESE-3A, Net, ABT1 and ERF. Members of the Ets gene family exhibit varied patterns of tissue expression, and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. Several of these proteins have been shown to recognize similar motifs in DNA that share a centrally located 5'-GGAA-3' element.

Function:
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

Subcellular Location:
Nucleus.

Tissue Specificity:
In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.

DISEASE:
Genetic variation in FEV may be associated with susceptibility to sudden infant death syndrome (SIDS) [MIM:272120]. SIDS remains elusive in its causes and devastating in its consequences. Despite the impressive decline in the incidence of SIDS since the recommendation to avoid the prone sleep position, SIDS remains a leading cause of death in the first year of life. Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.

Database links:
Entrez Gene: 524933 Cow
Entrez Gene: 100723616 Guinea pig
Entrez Gene: 54738 Human
Entrez Gene: 260298 Mouse
Entrez Gene: 246271 Rat
Omim: 607150 Human
SwissProt: Q99581 Human
SwissProt: Q8QZW2 Mouse
SwissProt: O70132 Rat
Unigene: 234759 Human
Unigene: 150496 Mouse
Unigene: 83616 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application

Ets-1是一个基因家族的原型成员,该家族的基因与从E26红细胞生成病毒中分离的v-Ets癌基因同源性。该基因家族目前包括Ets-1、Ets-2、Erg-1-3、Elk-1、Elf-1、Elf-5、NERF、PU.1、PEA3、ERM、FEV、ER8l、Fli-1、TEL、Spi-B、ESE-1、ESE-3A、Net、ABT1和ERF。Ets基因家族的成员表现出不同的组织表达模式,并且共享高度保守的羧基末端结构域,该结构域包含与SV40大T抗原核定位信号序列相关的序列。这个保守结构域对于Ets-1与DNA的结合是必不可少的,并且很可能负责Ets基因家族的所有成员的DNA结合活性。这些蛋白中有几个已经显示出在DNA中识别出类似的基序,这些基序共享位于中心的5'-GGAA-3'元件。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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