Rabbit Anti-COPS3/FITC Conjugated antibody
|别 名||COP9 Signalosome Complex Subunit 3; CSN10; JAB1 Containing Signalosome Subunit 3; SGN3; Signalosome Subunit 3; CSN3_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 细胞周期蛋白 激酶和***酸酶|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||48kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human COPS3|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG.
Cytoplasmic and Nuclear.
Widely expressed. Expressed at high level in heart and skeletal muscle.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Belongs to the CSN3 family.
Contains 1 PCI domain.
Entrez Gene: 8533 Human
Entrez Gene: 26572 Mouse
Entrez Gene: 287367 Rat
Omim: 604665 Human
SwissProt: Q9UNS2 Human
SwissProt: O88543 Mouse
SwissProt: Q68FW9 Rat
Unigene: 6076 Human
Unigene: 40 Mouse
Unigene: 3963 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因编码的蛋白具有***酸化参与信号转导的调节因子的激酶活性。它***酸化I kappa-Balpha，p105和c-Jun。它充当复杂介导***酸化的对接位点。该基因位于17号染色体上的Smith-MaMeNIS综合征区域内。发现了两个编码不同亚型的转录变体。[ RefSeq，NOV 2010 ]提供。