FITC标记的COP9信号复合体亚基3抗体上海沪震实业有限公司

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产品名称: FITC标记的COP9信号复合体亚基3抗体
英文名称: Anti-COPS3/FITC
抗体货号: HZ-23085R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 15:11:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-COPS3/FITC Conjugated antibody

FITC标记的COP9信号复合体亚基3抗体

 

英文名称 Anti-COPS3/FITC
中文名称 FITC标记的COP9信号复合体亚基3抗体
别    名 COP9 Signalosome Complex Subunit 3; CSN10; JAB1 Containing Signalosome Subunit 3; SGN3; Signalosome Subunit 3; CSN3_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  细胞周期蛋白  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应  
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human COPS3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Subunit:
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG.

Subcellular Location:
Cytoplasmic and Nuclear.

Tissue Specificity:
Widely expressed. Expressed at high level in heart and skeletal muscle.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the CSN3 family. 
Contains 1 PCI domain.

Database links:

Entrez Gene: 8533 Human

Entrez Gene: 26572 Mouse

Entrez Gene: 287367 Rat

Omim: 604665 Human

SwissProt: Q9UNS2 Human

SwissProt: O88543 Mouse

SwissProt: Q68FW9 Rat

Unigene: 6076 Human

Unigene: 40 Mouse

Unigene: 3963 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码的蛋白具有***酸化参与信号转导的调节因子的激酶活性。它***酸化I kappa-Balpha,p105和c-Jun。它充当复杂介导***酸化的对接位点。该基因位于17号染色体上的Smith-MaMeNIS综合征区域内。发现了两个编码不同亚型的转录变体。[ RefSeq,NOV 2010 ]提供。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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