FITC标记的唾液酸结合性免疫球蛋白样凝集素7抗体上海沪震实业有限公司

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产品名称: FITC标记的唾液酸结合性免疫球蛋白样凝集素7抗体
英文名称: Anti-SIGLEC7/FITC
抗体货号: HZ-10103R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/5 15:26:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-SIGLEC7/FITC Conjugated antibody

FITC标记的唾液酸结合性免疫球蛋白样凝集素7抗体

 

英文名称 Anti-SIGLEC7/FITC
中文名称 FITC标记的唾液酸结合性免疫球蛋白样凝集素7抗体
别    名 Sialic Acid Binding Ig-Like Lectin 7; AIRM1; QA79 Membrane Protein; SIGLEC-7; D-Siglec; AIRM-1; CDw328; P75; Sialic Acid Binding Ig-Like Lectin 19, Pseudogene; Adhesion Inhibitory Receptor Molecule 1, Siglec-7; Sialic Acid Binding Ig-Like Lectin, Pseudogene 2; Sialic Acid Binding Immunoglobulin-Like Lectin 7; Adhesion Inhibitory Receptor Molecule 1; Sialic Acid-Binding Ig-Like Lectin 7; CD328 Antigen; P75/AIRM1; SIGLEC19P; SIGLECP2; CD328; QA79; SIGL7_HUMAN;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  免疫学  神经生物学  干细胞  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIGLEC7
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Siglec 7 is a member of the Siglec (sialic acid-binding immunoglobulin like lectin) subgroup of the immunoglobulin superfamily. Siglec 7 is able to mediate high levels of sialic acid-dependent binding to human erythrocytes and soluble sialoglycoconjugates. Addition of anti-Siglec 7 to haematopoietic cell cultures leads to reduced cell growth and prevents the development of dendritic cells. Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression can be found in tissues like the placenta, liver, lung, spleen, and peripheral blood leukocytes.

Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Post-translational modifications:
Tyrosine phosphorylated.

Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 27036 Human

Omim: 604410 Human

SwissProt: Q9Y286 Human

Unigene: 274470 Human

Unigene: 655393 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

Siglit of the Member of the Siglet(Sialic acid - binding imunogobobobu林like Lie Lecin)6 .第7条是一个可供衡量的高水平的中等收入国家。7 .在第7号一般性意见中,第7条规定:一般说来,按Granulocytes和Monocytes的规定,恢复和启动自然杀手细胞和卫星。High expression can be found in tissues like the胎盘、Liver,luns,pleen,and performeral Blood Loukocytes .

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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