Rabbit Anti-C1orf173/FITC Conjugated antibody
|别 名||C1orf173; CA173_HUMAN; Chromosome 1 open reading frame 173; DKFZp547I048; DKFZp761G1720; DKFZp781L0319; Hypothetical protein LOC127254; MGC90412; OTTHUMP00000011196; RP11-653A5.1; Uncharacterized protein C1orf173.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 免疫学 神经生物学|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||168kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human C1orf173|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf173 gene product has been provisionally designated C1orf173 pending further characterization. There are three isoforms of C1orf173 that are produced as a result of alternative splicing events.
Entrez Gene: 127254 Human
SwissProt: Q5RHP9 Human
Unigene: 531182 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
染色体1是最大的人类染色体，跨越约2.6亿个碱基对，占人类基因组的8%。1号染色体上约有3000个基因，考虑到基因数量众多，还有大量与1号染色体相关的疾病。值得注意的是，罕见的老化性疾病Hutchinson-Gilford progeria与编码层粘连蛋白A的LMNA基因有关。当有缺陷时，LMNA基因产物可在细胞核内积聚并引起特征性核小泡。迅速增强衰老的机制尚不清楚，是一个继续探索的话题。MUTYH基因位于第1染色体上，部分与家族性腺瘤性息肉病有关。Stickler综合征、帕金森病、高切病和Usher综合征也与第1号染色体相关。1q基因已鉴定出一个断点，该断点破坏DISC1基因，与精神分裂症有关。染色体1异常存在于各种癌症中，包括头颈癌、恶性黑色素瘤和多发性骨髓瘤。C1orf173基因产物暂时命名为C1orf173，等待进一步鉴定。有三种异构体的C1ORF 173，作为替代剪接事件的结果而产生。