Anti-Histone H3 (Tri Methyl K4)抗体上海钰博生物科技有限公司



产品名称: Anti-Histone H3 (Tri Methyl K4)抗体
英文名称: Histone H3 (Tri Methyl K4)
抗体货号: YB--4715R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1580元
抗原: KLH conjugated Synthesised metylpeptide derived from human Histone H3 around the metylation site of Tri Methyl K4:RT(Tri Methyl-K)QT
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Pig, Cow, Rabbit, Fruit Fly,
应用范围: 科研使用
更新时间: 2019/4/19 16:15:00
详细资料:  实验方法技术资料
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 Anti-Histone H3 (Tri Methyl K4)抗体

产品编号 YB-4715R
英文名称 Histone H3 (Tri Methyl K4)
中文名称 三甲基化组蛋白H3抗体
别    名 Histone H3(Tri Methyl Lys4); Tri methyl Histone H3(Lys4); Tri methyl Histone H3(K4); H3 histone family member E pseudogene; H3F3; HIST3H3; Histone H3 3 pseudogene; Histone H3; H3S; Histone H3-I/H3-II; Major histone H3; H3F; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; H31_HUMAN.  
规格价格 100ul/1580元 购买        大包装/询价
说 明 书 100ul  
产品类型 甲基化抗体 
研究领域 肿瘤  细胞生物  免疫学  染色质和核信号  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Rabbit, Fruit Fly, 
产品应用 ELISA=1:500-1000  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised metylpeptide derived from human Histone H3 around the metylation site of Tri Methyl K4:RT(Tri Methyl-K)QT 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H3 is deposited into chromatin exclusively through a DNA replication-coupled pathway that can be associated with either DNA duplication or DNA repair synthesis during meiotic homologous recombination.

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with GCN5, whereby H3S10ph increases histone-protein interactions. Interacts with PDD1 and PDD3.

Subcellular Location:
Nucleus. Chromosome. Note=Localizes to both the large, transcriptionally active, somatic macronucleus (MAC) and the small, transcriptionally inert, germ line micronucleus (MIC).

Post-translational modifications:
Phosphorylated to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5. H3S10ph is only found in the mitotically dividing MIC, but not in the amitotically dividing MAC. H3S10ph is correlated with chromosome condensation during mitotic or meiotic micronuclear divisions. 
Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K9acK14ac is the preferred acetylated form of newly synthesized H3. Acetylation occurs almost exclusively in the MAC.
Methylated to form H3K4me. H3K4me is only found in the transcriptionally active MAC. Methylated to form H3K9me in developing MACs during conjugation, when genome-wide DNA elimination occurs. At this stage, H3K9me specifically occurs on DNA sequences being eliminated (IES), probably targeted by small scan RNAs (scnRNAs) bound to IES, and is required for efficient IES elimination. H3K9me is required for the interaction with the chromodomains of PDD1 and PDD3. 
The full-length protein H3S (slow migrating) is converted to H3F (fast migrating) by proteolytic removal of the first 6 residues. H3F is unique to MIC, and processing seems to occur regularly each generation at a specific point in the cell cycle.

Belongs to the histone H3 family.


Gene ID:

Database links:


Entrez Gene: 8290 Human

Entrez Gene: 8350 Human

Entrez Gene: 8351 Human

Entrez Gene: 8352 Human

Entrez Gene: 8353 Human

Entrez Gene: 8354 Human

Entrez Gene: 8355 Human

Entrez Gene: 8356 Human

Entrez Gene: 8357 Human

Entrez Gene: 8358 Human

Entrez Gene: 8968 Human

Entrez Gene: 260423 Mouse

Entrez Gene: 319148 Mouse

Entrez Gene: 319149 Mouse

Entrez Gene: 319150 Mouse

Entrez Gene: 319151 Mouse

Entrez Gene: 319152 Mouse

Entrez Gene: 319153 Mouse

Entrez Gene: 360198 Mouse

Entrez Gene: 97908 Mouse

Entrez Gene: 100364501 Rat

Entrez Gene: 100365669 Rat

Entrez Gene: 291159 Rat

Entrez Gene: 314977 Rat

Entrez Gene: 364716 Rat

Entrez Gene: 679950 Rat

Entrez Gene: 679994 Rat

Entrez Gene: 680511 Rat

Entrez Gene: 680599 Rat

Entrez Gene: 682330 Rat

Entrez Gene: 691496 Rat

Omim: 601128 Human

Omim: 602810 Human

Omim: 602811 Human

Omim: 602812 Human

Omim: 602813 Human

Omim: 602814 Human

Omim: 602815 Human

Omim: 602816 Human

Omim: 602817 Human

Omim: 602818 Human

Omim: 602819 Human

SwissProt: P68431 Human

SwissProt: P84243 Human

SwissProt: Q16695 Human

SwissProt: Q6NXT2 Human

SwissProt: Q71DI3 Human

SwissProt: P68433 Mouse

SwissProt: P84228 Mouse

SwissProt: Q6LED0 Rat

Unigene: 132854 Human

Unigene: 247813 Human

Unigene: 247814 Human

Unigene: 248176 Human

Unigene: 443021 Human

Unigene: 484990 Human

Unigene: 532144 Human

Unigene: 533292 Human

Unigene: 546315 Human

Unigene: 586261 Human

Unigene: 591778 Human

Unigene: 221301 Mouse

Unigene: 261657 Mouse

Unigene: 377874 Mouse

Unigene: 390558 Mouse

Unigene: 397328 Mouse

Unigene: 138090 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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