Anti-FBXL15抗体上海钰博生物科技有限公司

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产品名称: Anti-FBXL15抗体
英文名称: FBXL15
抗体货号: YB--8475R
产品规格: 20ul/50ul/100ul/200ul
级    别: 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 1580元
抗原: KLH conjugated synthetic peptide derived from human FBXL15:201-300/300
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/1/14 10:01:00
详细资料:  实验方法技术资料
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诚信指数:1562点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-FBXL15抗体

产品编号 YB-8475R
英文名称 FBXL15
中文名称 FBXL15蛋白抗体
别    名 F box and leucine rich repeat protein 15; F box only protein 37; F box/LRR repeat protein 15; Fbl15; FBXO37; FLJ16137; JET; OTTHUMP00000020367; OTTHUMP00000059115; OTTHUMP00000059124; OTTHUMP00000059125; Pleckstrin and Sec7 domain protein; PSD; MGC11279; FXL15_HUMAN.  
规格价格 100ul/1580元 购买    200ul/2480元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
细胞定位 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXL15:201-300/300 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
FBXL15 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors. FBL15 (F-box and leucine-rich repeat protein 15), also known as FBXL15, FBXO37, PSD or JET, is a 296 amino acid protein that contains one F-box domain and functions as a component of the SCF complex, possibly playing a role in the ubiquitination and subsequent degradation of target proteins.

Function:
Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. 

Subunit:
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the FBXL15 family. 
Contains 1 F-box domain. 
Contains 5 LRR (leucine-rich) repeats. 

SWISS:
Q9H469

Gene ID:
79176

Database links:

Entrez Gene: 79176 Human

Entrez Gene: 68431 Mouse

Omim: 610287 Human

SwissProt: Q9H469 Human

SwissProt: Q91W61 Mouse

Unigene: 380081 Human

Unigene: 19973 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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