|别 名||CDK5 activator binding protein C42 like; CDK5 regulatory subunit associated protein 1; CDK5RAP1.3; CDK5RAP1.4; CGI 05; HSPC167; C20orf34 antibody C42; CDK5 activator binding protein C42; CK5P1_HUMAN.|
|规格价格||100ul/1580元 购买 200ul/2480元 购买 大包装/询价|
|说 明 书||100ul 200ul|
|研究领域||细胞生物 免疫学 激酶和***酸酶 结合蛋白|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||68kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human CDK5RAP1:301-400/601|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Cyclin dependent kinase 5 (Cdk5) is a key regulator of cell cycle progression in neuronal differentiation that physically associates with and is activated by the neuron-specific protein p35. CDK5RAP1 (Cdk5 regulatory subunit-associated protein 1), also known as Cdk5 activator-binding protein C42, is a 601 amino acid protein that specifically inhibits Cdk5 activation by p35 through formation of a dimer that inhibits kinase activity. CDK5RAP1 contains one TRAM domain, which is thought to bind tRNA and deliver the RNA-modifying enzymatic domain to its target. There are 4 named isoforms of CDK5RAP1 that are produced as a result of alternative splicing events and are expressed at high levels in heart and skeletal muscle.
Specifically inhibits CDK5 activation by CDK5R1.
Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Belongs to the methylthiotransferase family. MiaB subfamily.
Contains 1 MTTase N-terminal domain.
Contains 1 TRAM domain.
Entrez Gene: 51654 Human
Entrez Gene: 66971 Mouse
Entrez Gene: 252827 Rat
Omim: 608200 Human
SwissProt: Q96SZ6 Human
SwissProt: Q8BTW8 Mouse
SwissProt: Q9JLH6 Rat
Unigene: 435952 Human
Unigene: 289427 Mouse
Unigene: 203271 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications